Ptpra - protein tyrosine phosphatase, receptor type, A Gene

Mus musculus

Also known as Ptpa; Rptra; Ptpalpha; Rptpalpha; Rptralpha

Gene ID: 19262 | Gene type: protein coding

About Ptpra

Summary

Enables protein tyrosine Phosphatase activity. Involved in integrin-mediated signaling pathway; modulation of chemical synaptic transmission; and regulation of focal adhesion assembly. Acts upstream of or within Insulin Receptor signaling pathway and protein phosphorylation. Located in focal adhesion and membrane. Is active in Schaffer collateral - CA1 synapse. Is integral component of synaptic membrane. Is expressed in several structures, including adrenal gland; central nervous system; decidua; extraembryonic component; and future brain. Orthologous to human PTPRA (protein tyrosine Phosphatase receptor type A). [provided by Alliance of Genome Resources, Apr 2022]

Ptpra Products(3)

mRNA	Protein	Name
NM_001163688.1	NP_001157160.1	receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor
NM_001355161.1	NP_001342090.1	receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor
NM_008980.2	NP_033006.2	receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7518772	MGI
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	22801373	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14733908	MGI
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22801373	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12912911	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12912911	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	14733908	MGI
involved in regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	22801373	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	12912911	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	12912911	MGI
located in focal adhesion	IMP IMP: Inferred from mutant phenotype	22801373	MGI
located in membrane	IMP IMP: Inferred from mutant phenotype	22801373	MGI
is active in synaptic membrane	IDA IDA: Inferred from direct assay	16899073	MGI
is active in synaptic membrane	IEP IEP: Inferred from expression pattern	16899073	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase alpha

LCA-related phosphatase	PTPTY-28
R-PTP-alpha	protein-tyrosine phosphatase alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176305S	Neurofilament, U-15N		/	Unkown
HY-RS11432	PTPRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19478	Ptpra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25971	Ptpra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpra	NCBI	NCBI:5786

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