Nme1 - NME/NM23 nucleoside diphosphate kinase 1 Gene

Rattus norvegicus

Gene ID: 191575 | Gene type: protein coding

About Nme1

Summary

Enables several functions, including DNA binding activity; gamma-tubulin binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including cellular response to glucose stimulus; response to cAMP; and response to testosterone. Located in several cellular components, including centrosome; mitochondrial outer membrane; and perinuclear region of cytoplasm. Colocalizes with intermediate filament. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to human NME1 (NME/NM23 nucleoside diphosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nme1 Products(1)

mRNA	Protein	Name
NM_138548.2	NP_612557.1	nucleoside diphosphate kinase A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12010125	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	17572440	RGD
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	11139339	RGD
enables intermediate filament binding	IPI IPI: Inferred from physical interaction	11082283	RGD
enables nucleoside diphosphate kinase activity	IDA IDA: Inferred from direct assay	11139339	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11302744	RGD
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	12010125	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in GTP biosynthetic process	IDA IDA: Inferred from direct assay	11139339	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	19367376	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	19367376	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11082283	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	18493952	RGD
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	12010125	RGD
involved in negative regulation of myeloid leukocyte differentiation	IDA IDA: Inferred from direct assay	7737424	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	10069391	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	19639176	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	11082283	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	19639176	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11082283	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	11139339	RGD
located in intermediate filament	IDA IDA: Inferred from direct assay	11082283	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	22817458	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11082283	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nucleoside diphosphate kinase A

NDK A	NDP kinase A
NDP kinase beta	expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase)
metastasis inhibition factor NM23	non-metastatic cells 1, protein (NM23A) expressed in
nucloside diphosphate kinase	tumor metast

Nme1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Nme1	Q05982	MEN1	Homo sapiens	O00255-2	Y2H	11302744

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09371	NME1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09372	NME1-NME2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20309	Nme1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26817	Nme1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nme1	NCBI	NCBI:4830

Name
Email *

	Sorry, but the email address you supplied was invalid.