2. Gene
  3. Ppp3r1 - protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) Gene

Ppp3r1 - protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cnb1; CaNB1; MCIP1

Gene ID: 19058 | Gene type: protein coding

About Ppp3r1

Summary

Enables Phosphatase binding activity and phosphoprotein Phosphatase activity. Involved in postsynaptic modulation of chemical synaptic transmission and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including animal organ development; branching involved in blood vessel morphogenesis; and calcineurin-NFAT signaling cascade. Located in several cellular components, including Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and sarcolemma. Part of Calcineurin complex. Is active in synapse. Is expressed in brain; heart; jaw skeleton; and tooth. Used to study dilated cardiomyopathy and schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein Phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3r1 Products(1)

mRNA Protein Name
NM_024459.2 NP_077779.2 calcineurin subunit B type 1
Protein Preferred Names Protein Names

calcineurin subunit B type 1

PP2B beta 1

protein phosphatase 2B regulatory subunit 1

protein phosphatase 3 regulatory subunit B alpha

Ppp3r1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Ppp3r1 Q63810 Map3k5 Mus musculus O35099
Y2H
16648474
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11026 PPP3R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21913 Ppp3r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28430 Ppp3r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp3r1 NCBI NCBI:5534