Plcb1 - phospholipase C, beta 1 Gene

Mus musculus

Also known as Plcb; mKIAA0581; 3110043I21Rik

Gene ID: 18795 | Gene type: protein coding

About Plcb1

Summary

Enables lamin binding activity and phosphatidylinositol Phospholipase C activity. Involved in several processes, including positive regulation of cell cycle process; regulation of cellular macromolecule biosynthetic process; and regulation of trans-synaptic signaling. Located in several cellular components, including chromatin; glutamatergic synapse; and nuclear speck. Part of protein-containing complex. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study Alzheimer's disease and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 12 and myelodysplastic syndrome. Orthologous to human PLCB1 (Phospholipase C beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Plcb1 Products(2)

mRNA	Protein	Name
NM_001145830.1	NP_001139302.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1
NM_019677.2	NP_062651.2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lamin binding	IPI IPI: Inferred from physical interaction	19028838	MGI
enables phosphatidylinositol phospholipase C activity	IDA IDA: Inferred from direct assay	9762362	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17022104	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled acetylcholine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9305844	MGI
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	19028838	MGI
involved in activation of meiosis involved in egg activation	IDA IDA: Inferred from direct assay	14499343	MGI
involved in cerebral cortex development	IMP IMP: Inferred from mutant phenotype	11224545	MGI
involved in fat cell differentiation	IDA IDA: Inferred from direct assay	19385066	MGI
involved in glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11224545	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	9187110	MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	31268747	MGI
involved in ligand-gated ion channel signaling pathway	IMP IMP: Inferred from mutant phenotype	26075576	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	18493969	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12031797	MGI
involved in negative regulation of monocyte extravasation	IDA IDA: Inferred from direct assay	19687358	MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	10570150	MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	31268747	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26075576	MGI
involved in positive regulation of CD24 production	IDA IDA: Inferred from direct assay	15849202	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15849202	MGI
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	10913438	MGI
involved in positive regulation of acrosome reaction	IMP IMP: Inferred from mutant phenotype	11464583	MGI
involved in positive regulation of developmental growth	IMP IMP: Inferred from mutant phenotype	15474310	MGI
involved in positive regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	11464583	MGI
involved in positive regulation of insulin secretion	IGI IGI: Inferred from genetic interaction	10570150	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	26075576	MGI
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	9444325	MGI
involved in positive regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	15174099	MGI
involved in postsynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	16339037	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	16339037	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	16339037	MGI
involved in regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18493969	MGI
involved in regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	27653213	MGI
involved in regulation of fertilization	IMP IMP: Inferred from mutant phenotype	11464583	MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA IDA: Inferred from direct assay	15664177	MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid	IMP IMP: Inferred from mutant phenotype	15664177	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	15664177	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	15664177	MGI
located in chromatin	IDA IDA: Inferred from direct assay	19028838	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15849202	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	16339037	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16339037	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16339037	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	17022104	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10913438	MGI
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	18973591	MGI
is active in postsynaptic cytosol	IEP IEP: Inferred from expression pattern	18973591	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	27353086	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

PLC-154	PLC-beta-1
phosphoinositide phospholipase C	phosphoinositide phospholipase C-beta-1
phospholipase C-beta-1a

Plcb1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81881	Phospholipase C beta 1 Antibody (YA1626)	WB	Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10652	PLCB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21691	Plcb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28209	Plcb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plcb1	NCBI	NCBI:23236

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