Pitx1 - paired-like homeodomain transcription factor 1 Gene

Mus musculus

Also known as Bft; Potx; Ptx1; P-OTX

Gene ID: 18740 | Gene type: protein coding

About Pitx1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic hindlimb morphogenesis; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development; hindlimb morphogenesis; and myoblast fate commitment. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study clubfoot. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human PITX1 (paired like homeodomain 1). [provided by Alliance of Genome Resources, Apr 2022]

Pitx1 Products(1)

mRNA	Protein	Name
NM_011097.2	NP_035227.1	pituitary homeobox 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8675014	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8675014	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9192866	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within branchiomeric skeletal muscle development	IMP IMP: Inferred from mutant phenotype	17384148	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	10101115	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	18231602	MGI
involved in embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	22071103	MGI
acts upstream of or within hindlimb morphogenesis	IDA IDA: Inferred from direct assay	15621531	MGI
acts upstream of or within hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	10049363	MGI
acts upstream of or within myoblast fate commitment	IMP IMP: Inferred from mutant phenotype	17384148	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21300782	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	10049363	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9192866	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8675014	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10431247	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	10101115	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19531352	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19531352	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9192866	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pituitary homeobox 1

hindlimb-expressed homeobox protein backfoot	homeobox protein P-OTX
homeobox protein PITX1	pituitary OTX-related factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10581	PITX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21023	Pitx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27540	Pitx1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pitx1	NCBI	NCBI:5307

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