Pip5k1a - phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha Gene

Mus musculus

Also known as Pipk5a; PI4P5K-I[a]; PIP5KIalpha; PIP5K1-alpha

Gene ID: 18720 | Gene type: protein coding

About Pip5k1a

Summary

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Acts upstream of or within fibroblast migration and phosphatidylinositol biosynthetic process. Located in cytosol; nucleus; and ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pip5k1a Products(2)

mRNA	Protein	Name
NM_001293707.1	NP_001280636.1	phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1
NM_008847.3	NP_032873.2	phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA IDA: Inferred from direct assay	8798574	MGI
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IGI IGI: Inferred from genetic interaction	20622009	MGI
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IMP IMP: Inferred from mutant phenotype	27739494	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14701839	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within fibroblast migration	IMP IMP: Inferred from mutant phenotype	15870270	MGI
acts upstream of or within phosphatidylinositol biosynthetic process	IGI IGI: Inferred from genetic interaction	20622009	MGI
acts upstream of or within phosphatidylinositol metabolic process	IDA IDA: Inferred from direct assay	8798574	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	20622009	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15870270	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	15870270	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

68 kDa type I phosphatidylinositol 4-phosphate 5-kinase	68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
phosphatidylinositol 4-phosphate 5-kinase type I alpha	ptdIns(4)P-5-kinase 1 alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70631	PIP5K1A Recombinant Human Active Lipid Kinase		/	Unkown
HY-RS10566	PIP5K1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19547	Pip5k1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26043	Pip5k1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pip5k1a	NCBI	NCBI:8394

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