Pik3r2 - phosphoinositide-3-kinase regulatory subunit 2 Gene

Mus musculus

Also known as p85beta

Gene ID: 18709 | Gene type: protein coding

About Pik3r2

Summary

Enables phosphatidylinositol 3-kinase regulatory subunit binding activity and protein heterodimerization activity. Involved in several processes, including cellular glucose homeostasis; Insulin Receptor signaling pathway; and positive regulation of protein import into nucleus. Acts upstream of or within positive regulation of cell adhesion; regulation of actin filament organization; and regulation of protein localization to plasma membrane. Located in focal adhesion and nucleus. Is expressed in several structures, including early embryo; genitourinary system; liver; musculature; and spleen. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Pik3r2 Products(1)

mRNA	Protein	Name
NM_008841.3	NP_032867.2	phosphatidylinositol 3-kinase regulatory subunit beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol 3-kinase regulatory subunit binding	IPI IPI: Inferred from physical interaction	20348926	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12052866	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	20348926	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	20348926	MGI
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20348926	MGI
involved in intracellular glucose homeostasis	IDA IDA: Inferred from direct assay	20348926	MGI
acts upstream of or within positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	25217619	MGI
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	20348926	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20348926	MGI
acts upstream of or within regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	25217619	MGI
acts upstream of or within regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	25217619	MGI
acts upstream of or within regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	25217619	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	20348926	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	25217619	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20348926	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphatidylinositol 3-kinase regulatory subunit beta

PI3-kinase regulatory subunit beta	PI3-kinase subunit p85-beta
PI3K regulatory subunit beta	phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)	ptdIns-3-kinase regul

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-174976	FHND5032	Inhibitor	/	Unkown
HY-RS10537	PIK3R2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21907	Pik3r2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28424	Pik3r2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3r2	NCBI	NCBI:5296

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