Per1 - period circadian clock 1 Gene

Mus musculus

Also known as Per; Hftm; mPer1; m-rigui

Gene ID: 18626 | Gene type: protein coding

About Per1

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]

Per1 Products(2)

mRNA	Protein	Name
NM_001159367.2	NP_001152839.1	period circadian protein homolog 1
NM_011065.5	NP_035195.2	period circadian protein homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	24154698	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	24610784	MGI
enables kinase binding	IPI IPI: Inferred from physical interaction	14701732	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9856465	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	24413057	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	21680841	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	20159955	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15888647	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	14645221	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	15888647	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9856465	MGI
involved in negative regulation of glucocorticoid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24378737	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9989497	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12397359	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24610784	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24610784	MGI
involved in post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15888647	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	11395012	MGI
involved in regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	24610784	MGI
involved in response to cAMP	IDA IDA: Inferred from direct assay	23443664	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11591712	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

period circadian protein homolog 1

circadian clock protein PERIOD 1	circadian pacemaker protein Rigui
period homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125145	AA92593		99.94%	Unkown
HY-N10987	Spiranthesol		/	Unkown
HY-RS10331	PER1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19930	Per1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26432	Per1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Per1	NCBI	NCBI:5187

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