Pdx1 - pancreatic and duodenal homeobox 1 Gene

Mus musculus

Also known as Ipf1; IDX-1; IPF-1; Mody4; STF-1; pdx-1

Gene ID: 18609 | Gene type: protein coding

About Pdx1

Summary

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; pancreas development; and regulation of transcription by RNA polymerase II. Located in nuclear speck. Is expressed in several structures, including gut; liver and biliary system; reproductive system; sensory organ; and skeleton. Used to study maturity-onset diabetes of the young; maturity-onset diabetes of the young type 4; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdx1 Products(1)

mRNA	Protein	Name
NM_008814.4	NP_032840.1	pancreas/duodenum homeobox protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15486225	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12368292	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	19651901	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15121856	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14701942	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18155690	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	19619492	MGI
acts upstream of or within endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	18155690	MGI
acts upstream of or within enteroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	16418487	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18155690	MGI
acts upstream of or within exocrine pancreas development	IMP IMP: Inferred from mutant phenotype	16126192	MGI
acts upstream of or within glucose homeostasis	IGI IGI: Inferred from genetic interaction	20811152	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	18155690	MGI
acts upstream of or within glucose metabolic process	IDA IDA: Inferred from direct assay	12904469	MGI
acts upstream of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	20811152	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	19619492	MGI
acts upstream of or within morphogenesis of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	8625829	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18155690	MGI
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	20811152	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18155690	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17056599	MGI
acts upstream of or within negative regulation of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20811152	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	8625829	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12368292	MGI
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	12219087	MGI
acts upstream of or within positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	22253604	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14701942	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19799567	MGI
acts upstream of or within positive regulation of type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	18155690	MGI
acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12488434	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14701942	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12972592	MGI
acts upstream of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20811152	MGI
acts upstream of or within type B pancreatic cell differentiation	IMP IMP: Inferred from mutant phenotype	16418487	MGI
acts upstream of type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	18155690	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	10868931	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	15121856	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11287626	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pancreas/duodenum homeobox protein 1

insulin promoter factor 1, homeodomain transcription factor	islet/duodenum homeobox 1
pancreatic and duodenal homeobox gene 1	somatostatin-transactivating factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0777	Isorhamnetin-3-O-glucoside		99.96%	Unkown
HY-19694	BRD7552	Activator	99.32%	Unkown
HY-RS10295	PDX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20792	Pdx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27306	Pdx1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991294	MGTA-117 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdx1	NCBI	NCBI:3651

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