2. Gene
  3. Ocln - occludin Gene

Ocln - occludin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ocl

Gene ID: 18260 | Gene type: protein coding

About Ocln

Summary

Predicted to enable protein domain specific binding activity. Involved in negative regulation of gene expression and tight junction organization. Located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and bicellular tight junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Apr 2022]

Ocln Products(5)

mRNA Protein Name
NM_001360536.1 NP_001347465.1 occludin isoform 1
NM_001360537.1 NP_001347466.1 occludin isoform 1
NM_001360538.1 NP_001347467.1 occludin isoform 1
NM_001360539.1 NP_001347468.1 occludin isoform 2
NM_008756.2 NP_032782.1 occludin isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11782481 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21415414 MGI
involved in tight junction organization IMP
IMP: Inferred from mutant phenotype
30734065 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20089884 MGI
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
16520537 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
11025210 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12734665 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15528189 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11782481 MGI
located in tight junction IDA
IDA: Inferred from direct assay
23239027 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

occludin

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09743 OCLN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22265 Ocln Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ocln NCBI NCBI:100506658