Nfkbia - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Gene

Mus musculus

Also known as Nfkbi

Gene ID: 18035 | Gene type: protein coding

About Nfkbia

Summary

Predicted to enable several functions, including NF-kappaB binding activity; nuclear localization sequence binding activity; and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; and pattern recognition receptor signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; naris; and vibrissa follicle. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; hematologic Cancer (multiple); hepatitis B; hepatitis C; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Nfkbia Products(1)

mRNA	Protein	Name
NM_010907.2	NP_035037.2	NF-kappa-B inhibitor alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9223278	MGI
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	7963540	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	17367755	MGI
acts upstream of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	15845452	MGI
acts upstream of or within cellular response to biotic stimulus	IDA IDA: Inferred from direct assay	23262141	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	24349514	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	15845452	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	7963540	MGI
acts upstream of or within negative regulation of myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	15845452	MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 1 signaling pathway	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18505784	MGI
involved in positive regulation of transcription initiation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16322095	MGI
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	11799106	MGI
acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11799106	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21737317	MGI
acts upstream of or within response to exogenous dsRNA	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within response to muramyl dipeptide	IDA IDA: Inferred from direct assay	15692051	MGI
acts upstream of or within response to muscle stretch	IDA IDA: Inferred from direct assay	20442316	MGI
acts upstream of or within toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	18261938	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11799106	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11799106	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11799106	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NF-kappa-B inhibitor alpha

I(Kappa)B(alpha)	I-kappa-B-alpha
I-kappaBalpha	ikB-alpha
ikappaBalpha	nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
nuclear factor of kappa light polyp gene enhancer in B-cell 1

Nfkbia Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nfkbia	Q9Z1E3	Relb	Mus musculus	Q04863	Anti Bait CoIP	23086447
Intra	Nfkbia	Q9Z1E3	Rela	Mus musculus	Q04207	Anti Bait CoIP	20634424
Intra	Nfkbia	Q9Z1E3	Rela	Mus musculus	Q04207	Anti Bait CoIP	23850221
Intra	Nfkbia	Q9Z1E3	Rela	Mus musculus	Q04207	Anti Bait CoIP	23086447
Intra	Nfkbia	Q9Z1E3	Rela	Mus musculus	Q04207	Anti Bait CoIP	18401342

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09260	NFKBIA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18565	Nfkbia Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25048	Nfkbia Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfkbia	NCBI	NCBI:4792

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