Nfia - nuclear factor I/A Gene

Mus musculus

Also known as CTF; NF1A; NF1-A; 1110047K16Rik; 9430022M17Rik

Gene ID: 18027 | Gene type: protein coding

About Nfia

Summary

Enables DNA binding activity and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within synapse maturation and ureter development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in NFIA-related disorder. Orthologous to human NFIA (nuclear factor I A). [provided by Alliance of Genome Resources, Apr 2022]

Nfia Products(3)

mRNA	Protein	Name
NM_001122952.1	NP_001116424.1	nuclear factor 1 A-type isoform 1
NM_001122953.1	NP_001116425.1	nuclear factor 1 A-type isoform 3
NM_010905.3	NP_035035.1	nuclear factor 1 A-type isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12955085	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	23407945	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	29247144	MGI
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	29247144	MGI
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	29247144	MGI
acts upstream of or within cell quiescence	IMP IMP: Inferred from mutant phenotype	33004674	MGI
acts upstream of or within exit from mitosis	IMP IMP: Inferred from mutant phenotype	31128945	MGI
involved in gene expression	IGI IGI: Inferred from genetic interaction	29106906	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within generation of neurons	IMP IMP: Inferred from mutant phenotype	33004674	MGI
acts upstream of or within glial cell fate specification	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within glial cell proliferation	IMP IMP: Inferred from mutant phenotype	31128945	MGI
involved in limb morphogenesis	IMP IMP: Inferred from mutant phenotype	29247144	MGI
acts upstream of or within neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within neuron fate specification	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9056636	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19706729	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	33004674	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within synapse maturation	IMP IMP: Inferred from mutant phenotype	23407945	MGI
acts upstream of or within ureter development	IMP IMP: Inferred from mutant phenotype	17530927	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8306889	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear factor 1 A-type

CCAAT-box-binding transcription factor	TGGCA-binding protein
nuclear factor 1/A

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09249	NFIA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20782	Nfia Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27296	Nfia Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfia	NCBI	NCBI:4774

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