Nfe2l1 - nuclear factor, erythroid derived 2,-like 1 Gene

Mus musculus

Also known as NRF1; Lcrf1; TCF11; LCR-F1; TCF-11

Gene ID: 18023 | Gene type: protein coding

About Nfe2l1

Summary

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]

Nfe2l1 Products(7)

mRNA	Protein	Name
NM_001130450.1	NP_001123922.1	endoplasmic reticulum membrane sensor NFE2L1 isoform 1
NM_001130451.1	NP_001123923.1	endoplasmic reticulum membrane sensor NFE2L1 isoform 2
NM_001130452.1	NP_001123924.1	endoplasmic reticulum membrane sensor NFE2L1 isoform 2
NM_001130453.1	NP_001123925.1	endoplasmic reticulum membrane sensor NFE2L1 isoform 3
NM_001130454.1	NP_001123926.1	endoplasmic reticulum membrane sensor NFE2L1 isoform 4
NM_001361682.1	NP_001348611.1	endoplasmic reticulum membrane sensor NFE2L1 isoform 5
NM_008686.3	NP_032712.2	endoplasmic reticulum membrane sensor NFE2L1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10037736	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	22586274	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	29149604	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10037736	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	22586274	MGI
enables cholesterol binding	IDA IDA: Inferred from direct assay	29149604	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	25637874	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	25637874	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11342101	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	16581765	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16581765	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell redox homeostasis	IDA IDA: Inferred from direct assay	10601325	MGI
acts upstream of or within cellular homeostasis	IMP IMP: Inferred from mutant phenotype	29400713	MGI
involved in cellular response to cholesterol	IDA IDA: Inferred from direct assay	29149604	MGI
acts upstream of or within cellular response to cholesterol	IMP IMP: Inferred from mutant phenotype	29149604	MGI
acts upstream of or within cellular response to cold	IMP IMP: Inferred from mutant phenotype	29400713	MGI
acts upstream of or within cellular response to copper ion	IMP IMP: Inferred from mutant phenotype	24462598	MGI
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	10601325	MGI
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	29149604	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	29149604	MGI
acts upstream of or within cysteine transport	IMP IMP: Inferred from mutant phenotype	25092871	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	9501099	MGI
acts upstream of or within fructose 6-phosphate metabolic process	IMP IMP: Inferred from mutant phenotype	25041126	MGI
acts upstream of or within glial cell fate commitment	IDA IDA: Inferred from direct assay	23840004	MGI
acts upstream of or within glucose 6-phosphate metabolic process	IMP IMP: Inferred from mutant phenotype	25041126	MGI
acts upstream of or within glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	25092871	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	22586274	MGI
acts upstream of or within mitotic metaphase	IMP IMP: Inferred from mutant phenotype	22971132	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10037736	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24462598	MGI
acts upstream of or within protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	21554501	MGI
acts upstream of or within regulation of fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	25092871	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25041126	MGI
acts upstream of or within regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	25041126	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	29149604	MGI
acts upstream of or within regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	25092871	MGI
acts upstream of or within regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	22971132	MGI
acts upstream of or within regulation of nucleus organization	IMP IMP: Inferred from mutant phenotype	22971132	MGI
acts upstream of or within regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	27920251	MGI
acts upstream of or within regulation of response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	29400713	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25637874	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20385086	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22971132	MGI
acts upstream of or within response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	25637874	MGI
acts upstream of or within response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	23702335	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	21554501	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	29400713	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	25290918	MGI
located in nucleus	IDA IDA: Inferred from direct assay	29149604	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	16581765	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

endoplasmic reticulum membrane sensor NFE2L1

NF-E2-related factor 1	NFE2-related factor 1
locus control region-factor 1	nuclear factor erythroid 2-related factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09244	NFE2L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21165	Nfe2l1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfe2l1	NCBI	NCBI:4779

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