Nfatc2 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 Gene

Mus musculus

Also known as NFAT1; Nfatp; NF-ATp; NF-ATc2; NFAT1-D

Gene ID: 18019 | Gene type: protein coding

About Nfatc2

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of gene expression. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; myotube cell development; and positive regulation of myoblast fusion. Located in chromatin; cytosol; and nucleus. Part of ribonucleoprotein complex and transcription regulator complex. Is expressed in several structures, including brain; genitourinary system; jaw; spinal cord; and thymus primordium. Orthologous to human NFATC2 (nuclear factor of activated T cells 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc2 Products(16)

mRNA	Protein	Name
NM_001037177.2	NP_001032254.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform b
NM_001037178.2	NP_001032255.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform c
NM_001136073.2	NP_001129545.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform d
NM_001291168.1	NP_001278097.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform e
NM_001291169.1	NP_001278098.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform f
NM_001291170.1	NP_001278099.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform g
NM_001291171.1	NP_001278100.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform h
NM_001291172.1	NP_001278101.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform i
NM_001291173.1	NP_001278102.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform j
NM_001291174.1	NP_001278103.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform k
NM_001291175.1	NP_001278104.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform k
NM_001291176.1	NP_001278105.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform h
NM_001291177.1	NP_001278106.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform g
NM_001291178.1	NP_001278107.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform j
NM_001291179.1	NP_001278108.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform c
NM_010899.3	NP_035029.2	nuclear factor of activated T-cells, cytoplasmic 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8235597	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15319455	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	24161931	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12453415	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8235597	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24301466	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8943202	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7650004	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19752193	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	24301466	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcineurin-NFAT signaling cascade	IGI IGI: Inferred from genetic interaction	18676376	MGI
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	10620601	MGI
acts upstream of or within cellular response to calcium ion	IDA IDA: Inferred from direct assay	23259949	MGI
acts upstream of or within cytokine production	IDA IDA: Inferred from direct assay	15790681	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	23259949	MGI
acts upstream of or within lncRNA transcription	IMP IMP: Inferred from mutant phenotype	29475982	MGI
acts upstream of or within myotube cell development	IMP IMP: Inferred from mutant phenotype	18676376	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12453415	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19752193	MGI
acts upstream of or within positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	12757709	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8235597	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24301466	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24161931	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24301466	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	24161931	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	23259949	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	8668213	MGI
located in cytosol	IDA IDA: Inferred from direct assay	8235597	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	23259949	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8235597	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	21709260	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	8235597	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	19561615	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear factor of activated T-cells, cytoplasmic 2

NFAT pre-existing subunit

T-cell transcription factor NFAT1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09239	NFATC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-162280	PROTAC BTK Degrader-9		/	Unkown
HY-RS09240	NFATC2IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19067	Nfatc2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25557	Nfatc2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfatc2	NCBI	NCBI:4773

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