Nedd8 - neural precursor cell expressed, developmentally down-regulated gene 8 Gene

Mus musculus

Also known as Rub1; NEDD-8

Gene ID: 18002 | Gene type: protein coding

About Nedd8

Summary

Predicted to enable protein tag and ubiquitin protein Ligase binding activity. Acts upstream of or within protein localization and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2022]

Nedd8 Products(1)

mRNA	Protein	Name
NM_008683.4	NP_032709.1	NEDD8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12215427	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within protein localization	IDA IDA: Inferred from direct assay	12215427	MGI
involved in regulation of postsynapse assembly	EXP EXP: Inferred from Experiment	25581363	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	25581363	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	25581363	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12215427	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	25581363	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25581363	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25581363	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12215427	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NEDD8

neddylin	neural precursor cell expressed developmentally down-regulated protein 8
ubiquitin-like protein Nedd8

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-70062	Pevonedistat		99.98%	Phase 3
HY-10484	Pevonedistat hydrochloride		99.19%	Phase 3
HY-128586	TAS4464	Inhibitor	99.52%	Phase 1
HY-128586A	TAS4464 hydrochloride	Inhibitor	98.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108702	ML-792	Inhibitor	99.76%	Unkown
HY-101790A	ZM223 hydrochloride	Inhibitor	98.93%	Unkown
HY-115537	NAE-IN-M22	Activator	99.94%	Unkown
HY-101790	ZM223	Inhibitor	/	Unkown
HY-163105	Tubulin/NEDDylation-IN-1	Inhibitor	98.03%	Unkown
HY-159601	CSN5-IN-1	Inhibitor	/	Unkown
HY-RS09181	NEDD8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17081	Nedd8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23525	Nedd8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nedd8	NCBI	NCBI:4738

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