Nck1 - non-catalytic region of tyrosine kinase adaptor protein 1 Gene

Mus musculus

Also known as Nck; Nck-1; 6330586M15Rik; D230010O13Rik

Gene ID: 17973 | Gene type: protein coding

About Nck1

Summary

Enables Ephrin Receptor binding activity; eukaryotic initiation factor eIF2 binding activity; and protein domain specific binding activity. Involved in regulation of cellular macromolecule biosynthetic process and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including Ephrin Receptor signaling pathway; plasma membrane bounded cell projection assembly; and positive regulation of cellular component organization. Located in cell-cell junction and vesicle membrane. Is expressed in several structures, including extraembryonic component; hemolymphoid system gland; male reproductive gland or organ; nervous system; and somite. Orthologous to human NCK1 (NCK adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nck1 Products(2)

mRNA	Protein	Name
NM_001324530.1	NP_001311459.1	cytoplasmic protein NCK1 isoform 2
NM_010878.3	NP_035008.2	cytoplasmic protein NCK1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	19505147	MGI
enables eukaryotic initiation factor eIF2 binding	IPI IPI: Inferred from physical interaction	11959995	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14580336	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	8438166	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	12637565	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	12637565	MGI
acts upstream of or within ephrin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19505147	MGI
acts upstream of or within lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	12808099	MGI
involved in negative regulation of PERK-mediated unfolded protein response	IGI IGI: Inferred from genetic interaction	14676213	MGI
involved in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IGI IGI: Inferred from genetic interaction	14676213	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16835242	MGI
acts upstream of or within positive regulation of actin filament polymerization	IGI IGI: Inferred from genetic interaction	17923684	MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16835242	MGI
acts upstream of or within positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	19505147	MGI
involved in positive regulation of translation in response to endoplasmic reticulum stress	IGI IGI: Inferred from genetic interaction	14676213	MGI
acts upstream of or within regulation of cell migration	IGI IGI: Inferred from genetic interaction	19505147	MGI
involved in response to endoplasmic reticulum stress	IGI IGI: Inferred from genetic interaction	16835242	MGI
acts upstream of or within response to other organism	IMP IMP: Inferred from mutant phenotype	22966049	MGI
acts upstream of or within substrate-dependent cell migration, cell extension	IGI IGI: Inferred from genetic interaction	19414610	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in vesicle membrane	IDA IDA: Inferred from direct assay	12147689	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytoplasmic protein NCK1

NCK adaptor protein 1

Nck1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nck1	Q99M51	Tnk2	Mus musculus	O54967	Anti Bait CoIP	16777958
Intra	Nck1	Q99M51	Abl1	Mus musculus	P00520	Anti Tag CoIP	15148308
Intra	Nck1	Q99M51	Dok1	Mus musculus	P97465	Anti Tag CoIP	15148308
Intra	Nck1	Q99M51	Dok1	Mus musculus	P97465	Pull Down	20697350
Intra	Nck1	Q99M51	Dok1	Mus musculus	P97465	Anti Bait CoIP	15148308

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09080	NCK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18777	Nck1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25265	Nck1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nck1	NCBI	NCBI:4690

Name
Email *

	Sorry, but the email address you supplied was invalid.