Myo1c - myosin IC Gene

Mus musculus

Also known as NMI; MMIb; myr2; MYO1E; mm1beta

Gene ID: 17913 | Gene type: protein coding

About Myo1c

Summary

This gene encodes a member of the unconventional Myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Myo1c Products(4)

mRNA	Protein	Name
NM_001080774.2	NP_001074243.1	unconventional myosin-Ic isoform b
NM_001080775.2	NP_001074244.1	unconventional myosin-Ic isoform a
NM_001370611.2	NP_001357540.1	unconventional myosin-Ic isoform c
NM_008659.4	NP_032685.1	unconventional myosin-Ic isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microfilament motor activity	EXP EXP: Inferred from Experiment	19046570	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15976448	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	19144319	MGI
acts upstream of or within positive regulation of cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	12490950	MGI
acts upstream of or within positive regulation of cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	12490950	MGI
acts upstream of or within positive regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	12490950	MGI
acts upstream of or within positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	12490950	MGI
acts upstream of or within vesicle transport along actin filament	IDA IDA: Inferred from direct assay	12490950	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in brush border	IDA IDA: Inferred from direct assay	15758024	MGI
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	12490950	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	19144319	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12490950	MGI
located in stereocilium	IDA IDA: Inferred from direct assay	17050716	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

unconventional myosin-Ic

MMI-beta	myosin I beta
myosin-Ibeta	myosin-Ic
nuclear myosin I beta

Myo1c Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Myo1c	Q9WTI7	Plekhb1	Mus musculus	Q9QYE9-1	Anti Tag CoIP	15976448
Intra	Myo1c	Q9WTI7	Plekhb1	Mus musculus	Q9QYE9-1	Pull Down	15976448
Intra	Myo1c	Q9WTI7	Plekhb1	Mus musculus	Q9QYE9-2	Y2H	15976448
Intra	Myo1c	Q9WTI7	Plekhb1	Mus musculus	Q9QYE9-2	Pull Down	15976448

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08939	MYO1C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08941	MYO1E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21659	Myo1c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28177	Myo1c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo1c	NCBI	NCBI:4641

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