2. Gene
  3. Gadd45b - growth arrest and DNA-damage-inducible 45 beta Gene

Gadd45b - growth arrest and DNA-damage-inducible 45 beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Myd118

Gene ID: 17873 | Gene type: protein coding

About Gadd45b

Summary

Acts upstream of or within negative regulation of protein kinase activity; positive regulation of MAPK cascade; and regulation of cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including arterial system; forelimb bud; future brain; sensory organ; and somite. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta). [provided by Alliance of Genome Resources, Apr 2022]

Gadd45b Products(1)

mRNA Protein Name
NM_008655.1 NP_032681.1 growth arrest and DNA damage-inducible protein GADD45 beta
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12124778 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
12124778 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
12213961 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
12124778 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth arrest and DNA damage-inducible protein GADD45 beta

myeloid differentiation primary response gene 118

myeloid differentiation primary response protein MyD118

negative growth regulatory protein MyD118

Gadd45b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Gadd45b P22339 GADD45GIP1 Homo sapiens Q8TAE8
Pull Down
12716909
Cross
Gadd45b P22339 GADD45GIP1 Homo sapiens Q8TAE8
Anti Tag CoIP
12716909
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05230 GADD45B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18014 Gadd45b Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24487 Gadd45b Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gadd45b NCBI NCBI:4616