2. Gene
  3. Mx2 - MX dynamin-like GTPase 2 Gene

Mx2 - MX dynamin-like GTPase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mx-2

Gene ID: 17858 | Gene type: protein coding

About Mx2

Summary

This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral Infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to vesicular stomatitis virus, a member of the rhabdovirus family, but not to Influenza Virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a frameshift that inactivates this gene product. [provided by RefSeq, Jul 2008]

Mx2 Products(1)

mRNA Protein Name
NM_013606.1 NP_038634.1 interferon-induced GTP-binding protein Mx2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
11266216 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
involved in response to type I interferon IDA
IDA: Inferred from direct assay
11266216 MGI
involved in response to virus IDA
IDA: Inferred from direct assay
11266216 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon-induced GTP-binding protein Mx2

myxovirus (influenza virus) resistance 2

myxovirus resistance protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08860 MX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N14477 Saframycin Mx2 Inhibitor / Unkown
HY-RS18119 Mx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24593 Mx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mx2 NCBI NCBI:4600