Map1a - microtubule-associated protein 1 A Gene

Mus musculus

Also known as Mtap1; moth1; Mtap-1; Mtap1a; 6330416M19Rik

Gene ID: 17754 | Gene type: protein coding

About Map1a

Summary

Enables cytoskeletal anchor activity; cytoskeletal protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including axo-dendritic protein transport; learning or memory; and negative regulation of protein localization to microtubule. Acts upstream of or within photoreceptor cell maintenance and sensory perception of sound. Located in several cellular components, including axon initial segment; dendritic microtubule; and photoreceptor outer segment. Is expressed in cerebral cortex marginal zone; cortical plate; cortical subplate; and spinal cord. Orthologous to human MAP1A (microtubule associated protein 1A). [provided by Alliance of Genome Resources, Apr 2022]

Map1a Products(2)

mRNA	Protein	Name
NM_001173506.1	NP_001166977.1	microtubule-associated protein 1A isoform 2
NM_032393.2	NP_115769.1	microtubule-associated protein 1A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	26609151	MGI
enables cytoskeletal anchor activity	IDA IDA: Inferred from direct assay	26609151	MGI
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	26609151	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	17360631	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11925566	MGI
enables tubulin binding	IDA IDA: Inferred from direct assay	26609151	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterograde axonal protein transport	IGI IGI: Inferred from genetic interaction	26609151	MGI
involved in associative learning	IMP IMP: Inferred from mutant phenotype	26609151	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	26609151	MGI
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25788676	MGI
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	26609151	MGI
involved in negative regulation of protein localization to microtubule	IMP IMP: Inferred from mutant phenotype	25788676	MGI
involved in neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	25788676	MGI
involved in neuron projection maintenance	IMP IMP: Inferred from mutant phenotype	25788676	MGI
acts upstream of or within photoreceptor cell maintenance	IGI IGI: Inferred from genetic interaction	22323461	MGI
involved in positive regulation of protein localization	IMP IMP: Inferred from mutant phenotype	26609151	MGI
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	26609151	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	26609151	MGI
involved in retrograde axonal protein transport	IGI IGI: Inferred from genetic interaction	26609151	MGI
acts upstream of or within sensory perception of sound	IDA IDA: Inferred from direct assay	11925566	MGI
involved in voluntary musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	25788676	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon initial segment	IDA IDA: Inferred from direct assay	25788676	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11925566	MGI
located in dendrite	IDA IDA: Inferred from direct assay	25788676	MGI
located in dendritic microtubule	IDA IDA: Inferred from direct assay	25788676	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	25788676	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	24664738	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

microtubule-associated protein 1A

MAP-1A	modifier of tubby hearing 1
short MAP1A	short microtubule-associated protein 1A

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08026	MAP1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08348	METAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18394	Map1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24875	Map1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map1a	NCBI	NCBI:4130

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