2. Gene
  3. Mpz - myelin protein zero Gene

Mpz - myelin protein zero Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as P0; Mpp; P-zero

Gene ID: 17528 | Gene type: protein coding

About Mpz

Summary

This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I Transmembrane Glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2015]

Mpz Products(3)

mRNA Protein Name
NM_001315499.1 NP_001302428.1 myelin protein P0 isoform MPZ precursor
NM_001315500.1 NP_001302429.1 myelin protein P0 isoform L-MPZ precursor
NM_008623.5 NP_032649.2 myelin protein P0 isoform MPZ precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19423573 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell-cell junction maintenance IMP
IMP: Inferred from mutant phenotype
11749037 MGI
acts upstream of or within myelination IMP
IMP: Inferred from mutant phenotype
20731761 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myelin protein P0

myelin peripheral protein

Mpz Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Mpz P27573 Kcnma1 Mus musculus Q08460
Anti Bait CoIP
19423573
Intra
Mpz P27573 Kcnma1 Mus musculus Q08460
Confocal
19423573
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08633 MPZ Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22082 Mpz Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpz NCBI NCBI:4359