Trpm1 - transient receptor potential cation channel, subfamily M, member 1 Gene

Mus musculus

Also known as Mlsn1; Ltrpc1; 4732499L03Rik

Gene ID: 17364 | Gene type: protein coding

About Trpm1

Summary

Enables cation channel activity. Involved in cellular response to light stimulus. Acts upstream of or within cellular protein localization; retinal rod cell development; and signal transduction. Located in new growing cell tip. Is expressed in foregut; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in congenital stationary night blindness and congenital stationary night blindness 1C. Orthologous to human TRPM1 (transient receptor potential cation channel subfamily M member 1). [provided by Alliance of Genome Resources, Apr 2022]

Trpm1 Products(2)

mRNA	Protein	Name
NM_001039104.2	NP_001034193.2	transient receptor potential cation channel subfamily M member 1 isoform 2
NM_018752.3	NP_061222.3	transient receptor potential cation channel subfamily M member 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	19966281	MGI
enables monoatomic ion channel activity	IMP IMP: Inferred from mutant phenotype	36179691	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to light stimulus	IMP IMP: Inferred from mutant phenotype	19966281	MGI
involved in cellular response to light stimulus	IMP IMP: Inferred from mutant phenotype	19861548	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	31891182	MGI
acts upstream of or within retinal rod cell development	IMP IMP: Inferred from mutant phenotype	19966281	MGI
acts upstream of or within signal transduction	IGI IGI: Inferred from genetic interaction	19966281	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cell tip	IDA IDA: Inferred from direct assay	25997951	MGI
is active in dendrite	IDA IDA: Inferred from direct assay	25997951	MGI
located in new growing cell tip	IDA IDA: Inferred from direct assay	19966281	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily M member 1

long transient receptor potential channel 1

melastatin-1

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0151	Pregnenolone	99.87%	Unkown
HY-110189	Pregnenolone monosulfate sodium	99.96%	Unkown
HY-B1739	Pregnenolone monosulfate	99.96%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B0151R	Pregnenolone (Standard)		99.91%	Phase 4

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110220	CIM0216	Agonist	99.94%	Unkown
HY-101464	ML329	Inhibitor	98.0%	Unkown
HY-B0151S2	Pregnenolone-d4-1		99.34%	Unkown
HY-B0151S	Pregnenolone-d4		/	Unkown
HY-110189S	Pregnenolone monosulfate sodium-13C2,d2		/	Unkown
HY-110189S1	Pregnenolone monosulfate-d4 sodium		/	Unkown
HY-B0151S1	Pregnenolone-13C2,d2		99.2%	Unkown
HY-RS15111	TRPM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17998	Trpm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24470	Trpm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpm1	NCBI	NCBI:4308

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