Mesp1 - mesoderm posterior 1 Gene

Mus musculus

Also known as bHLHc5

Gene ID: 17292 | Gene type: protein coding

About Mesp1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; regulation of cell fate specification; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cardioblast anterior-lateral migration; mesodermal cell migration; and signal transduction involved in regulation of gene expression. Located in nucleus. Is expressed in several structures, including allantois; central nervous system; embryo mesenchyme; primitive streak; and sensory organ. Orthologous to human MESP1 (mesoderm posterior bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mesp1 Products(1)

mRNA	Protein	Name
NM_008588.2	NP_032614.2	mesoderm posterior protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18297060	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	18297060	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18297060	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18297060	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18593560	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac cell fate determination	IDA IDA: Inferred from direct assay	18593560	MGI
involved in cardioblast anterior-lateral migration	IMP IMP: Inferred from mutant phenotype	10393122	MGI
acts upstream of or within cardioblast migration	IMP IMP: Inferred from mutant phenotype	10393122	MGI
involved in cardioblast migration to the midline involved in heart field formation	IMP IMP: Inferred from mutant phenotype	10393122	MGI
involved in embryonic heart tube morphogenesis	IMP IMP: Inferred from mutant phenotype	10393122	MGI
involved in gastrulation	IEP IEP: Inferred from expression pattern	8787751	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	23352431	MGI
involved in growth involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	10393122	MGI
involved in heart induction	IDA IDA: Inferred from direct assay	18297060	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	10393122	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	10393122	MGI
involved in lateral mesoderm development	IMP IMP: Inferred from mutant phenotype	10393122	MGI
acts upstream of or within mesodermal cell migration	IGI IGI: Inferred from genetic interaction	10393122	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18593560	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18297060	MGI
involved in negative regulation of endodermal cell fate specification	IDA IDA: Inferred from direct assay	18593560	MGI
involved in negative regulation of mesodermal cell fate specification	IDA IDA: Inferred from direct assay	18593560	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18593560	MGI
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	18593560	MGI
involved in positive regulation of hepatocyte differentiation	IDA IDA: Inferred from direct assay	18593560	MGI
involved in positive regulation of striated muscle cell differentiation	IDA IDA: Inferred from direct assay	18593560	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18297060	MGI
involved in secondary heart field specification	IDA IDA: Inferred from direct assay	18593560	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
involved in sinus venosus morphogenesis	IMP IMP: Inferred from mutant phenotype	10393122	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	18593560	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mesoderm posterior protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08342	MESP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20447	Mesp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26956	Mesp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mesp1	NCBI	NCBI:55897

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