Mbd2 - methyl-CpG binding domain protein 2 Gene

Mus musculus

Also known as MBD2a

Gene ID: 17191 | Gene type: protein coding

About Mbd2

Summary

Enables chromatin binding activity and nucleic acid binding activity. Acts upstream of or within several processes, including maternal behavior; negative regulation of transcription by RNA polymerase II; and positive regulation of Wnt signaling pathway. Located in cytoplasm; heterochromatin; and nucleus. Part of histone deacetylase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb ectoderm; and retina. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MBD2 (methyl-CpG binding domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mbd2 Products(2)

mRNA	Protein	Name
NM_001311071.1	NP_001298000.1	methyl-CpG-binding domain protein 2 isoform 2
NM_010773.2	NP_034903.2	methyl-CpG-binding domain protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9774669	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16608912	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	23335972	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	15342650	MGI
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	15342650	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23335972	MGI
enables siRNA binding	IDA IDA: Inferred from direct assay	15342650	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18644872	MGI
acts upstream of or within maternal behavior	IMP IMP: Inferred from mutant phenotype	11274056	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11242117	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18644872	MGI
acts upstream of or within protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	11274056	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	18644872	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	9774669	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17546630	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	14519686	MGI
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	11274056	MGI
NOT located in nucleolus	IDA IDA: Inferred from direct assay	17546630	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9774669	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

methyl-CpG-binding domain protein 2

methyl-CpG-binding protein MBD2

testis-specific methyl-CpG binding protein 2

Mbd2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mbd2	Q9Z2E1	Mbd2	Mus musculus	Q9Z2E1	Anti Tag CoIP	23335972
Intra	Mbd2	Q9Z2E1	CHD4	Homo sapiens	F5GWX5	Anti Tag CoIP	26496610
Intra	Mbd2	Q9Z2E1	GATAD2B	Homo sapiens	Q8WXI9	Anti Tag CoIP	26496610
Intra	Mbd2	Q9Z2E1	GATAD2A	Homo sapiens	Q86YP4	Anti Tag CoIP	26496610
Intra	Mbd2	Q9Z2E1	DHX30	Homo sapiens	Q7L2E3-2	Anti Tag CoIP	26496610
Intra	Mbd2	Q9Z2E1	DHX36	Homo sapiens	Q9H2U1	Anti Tag CoIP	26496610
Intra	Mbd2	Q9Z2E1	Mbd2	Mus musculus	Q9Z2E1	Pull Down	23335972
Intra	Mbd2	Q9Z2E1	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	26496610
Intra	Mbd2	Q9Z2E1	CDK2AP1	Homo sapiens	F5GZF0	Anti Tag CoIP	26496610
Cross	Mbd2	Q9Z2E1	Mecp2	Rattus norvegicus	Q00566	Anti Tag CoIP	23335972
Cross	Mbd2	Q9Z2E1	Mecp2	Rattus norvegicus	Q00566	IF	23335972
Cross	Mbd2	Q9Z2E1	Mecp2	Rattus norvegicus	Q00566	Pull Down	23335972

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131031	KCC-07		99.95%	Unkown
HY-RS03948	DPEP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08182	MBD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17814	Mbd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18658	Dpep2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24283	Mbd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mbd2	NCBI	NCBI:8932

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