Trpm8 - transient receptor potential cation channel, subfamily M, member 8 Gene

Rattus norvegicus

Also known as CMR1

Gene ID: 171384 | Gene type: protein coding

About Trpm8

Summary

Enables ion channel activity. Involved in response to cold. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Apr 2022]

Trpm8 Products(1)

mRNA	Protein	Name
NM_134371.3	NP_599198.2	transient receptor potential cation channel subfamily M member 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	20214891	RGD
enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	11882888	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	22750945	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	11882888	RGD
involved in response to cold	IDA IDA: Inferred from direct assay	11882888	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane raft	IDA IDA: Inferred from direct assay	19176480	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily M member 8

cold menthol receptor 1

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-75161	(-)-Menthol	Activator	99.79%	Unkown
HY-B0985	Phenazopyridine hydrochloride	Antagonist	99.84%	Unkown
HY-B1173	(+)-Camphor	Inhibitor	≥98.0%	Unkown
HY-B0985A	Phenazopyridine	Antagonist	99.93%	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108449	Acoltremon	Agonist	99.13%	Phase 3
HY-109087	Elismetrep	Antagonist	99.42%	Phase 2
HY-112703	AMG 333	Antagonist	99.82%	Phase 1
HY-16162A	D-3263 hydrochloride	Agonist	98.03%	Phase 1
HY-115506	PF-05105679	Antagonist	99.84%	Phase 1
HY-16162	D-3263	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-11062	Icilin	Agonist	99.26%	Unkown
HY-100345	AMTB hydrochloride	Inhibitor	99.18%	Unkown
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-19960	BCTC		99.66%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-112430	TRPM8 antagonist 2	Antagonist	98.01%	Unkown
HY-19976	RN-1747	Agonist	99.25%	Unkown
HY-144372	TRPV1 antagonist 3	Antagonist	99.30%	Unkown
HY-110181	M8-B	Antagonist	99.89%	Unkown
HY-104059	AMG2850	Antagonist	99.89%	Unkown
HY-145124	TRPM8 antagonist 3	Antagonist	99.51%	Unkown
HY-N7117	1,4-Cineole	Activator	≥95.0%	Unkown
HY-W014394	Vanillyl butyl ether	Agonist	99.67%	Unkown
HY-110199	TC-I 2014	Antagonist	≥99.0%	Unkown
HY-160900	RN-1665	Antagonist	99.93%	Unkown
HY-130074	FEMA 4809	Agonist	99.25%	Unkown
HY-W014325	TRPM8 agonist WS-3	Agonist	99.35%	Unkown
HY-126593	Cryosim-3		99.90%	Unkown
HY-N7536	Voacangine		98.78%	Unkown
HY-104061	AMG8788	Antagonist	/	Unkown
HY-104062	AMG9678	Antagonist	/	Unkown
HY-108461	TRPM8-IN-1	Inhibitor	/	Unkown
HY-15056	AMG 9090	Agonist	/	Unkown
HY-RS15118	TRPM8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W711474	(-)-Menthol-d4		/	Unkown
HY-N1369S1	Menthol-d2	Modulator	/	Unkown
HY-N9484S	Menthofuran-13C2		/	Unkown
HY-RS16771	Trpm8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23211	Trpm8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpm8	NCBI	NCBI:79054

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