Trpm8 - transient receptor potential cation channel, subfamily M, member 8 Gene

Mus musculus

Also known as CMR1; TRPP8; LTRPC6; Trp-p8; LTrpC-6

Gene ID: 171382 | Gene type: protein coding

About Trpm8

Summary

Enables Calcium Channel activity and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in external side of plasma membrane. Is expressed in dorsal root ganglion; inferior vagus ganglion; and vagus ganglion. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Apr 2022]

Trpm8 Products(1)

mRNA	Protein	Name
NM_134252.5	NP_599013.1	transient receptor potential cation channel subfamily M member 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	11893340	MGI
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	17538622	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	17015441	MGI
enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	11893340	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18455988	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion transport	IDA IDA: Inferred from direct assay	17015441	MGI
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	11893340	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	22241835	MGI
acts upstream of or within response to cold	IDA IDA: Inferred from direct assay	12654248	MGI
acts upstream of or within response to cold	IMP IMP: Inferred from mutant phenotype	17481391	MGI
acts upstream of or within response to temperature stimulus	IDA IDA: Inferred from direct assay	11893340	MGI
acts upstream of or within thermoception	IDA IDA: Inferred from direct assay	12654248	MGI
acts upstream of or within thermoception	IMP IMP: Inferred from mutant phenotype	17481391	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17015441	MGI
located in membrane	IDA IDA: Inferred from direct assay	11893340	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	19176480	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily M member 8

TRP ion channel TRPM8	long transient receptor potential channel 6
transient receptor potential p8

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-75161	(-)-Menthol	Activator	99.79%	Unkown
HY-B0985	Phenazopyridine hydrochloride	Antagonist	99.84%	Unkown
HY-B1173	(+)-Camphor	Inhibitor	≥98.0%	Unkown
HY-B0985A	Phenazopyridine	Antagonist	99.93%	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108449	Acoltremon	Agonist	99.13%	Phase 3
HY-109087	Elismetrep	Antagonist	99.42%	Phase 2
HY-112703	AMG 333	Antagonist	99.82%	Phase 1
HY-16162A	D-3263 hydrochloride	Agonist	98.03%	Phase 1
HY-115506	PF-05105679	Antagonist	99.84%	Phase 1
HY-16162	D-3263	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-11062	Icilin	Agonist	99.26%	Unkown
HY-100345	AMTB hydrochloride	Inhibitor	99.18%	Unkown
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-19960	BCTC		99.66%	Unkown
HY-112430	TRPM8 antagonist 2	Antagonist	98.01%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-19976	RN-1747	Agonist	99.25%	Unkown
HY-144372	TRPV1 antagonist 3	Antagonist	99.30%	Unkown
HY-110181	M8-B	Antagonist	99.89%	Unkown
HY-104059	AMG2850	Antagonist	99.89%	Unkown
HY-145124	TRPM8 antagonist 3	Antagonist	99.51%	Unkown
HY-N7117	1,4-Cineole	Activator	≥95.0%	Unkown
HY-W014394	Vanillyl butyl ether	Agonist	99.67%	Unkown
HY-110199	TC-I 2014	Antagonist	≥99.0%	Unkown
HY-160900	RN-1665	Antagonist	99.93%	Unkown
HY-130074	FEMA 4809	Agonist	99.25%	Unkown
HY-W014325	TRPM8 agonist WS-3	Agonist	99.35%	Unkown
HY-126593	Cryosim-3		99.90%	Unkown
HY-N7536	Voacangine		98.78%	Unkown
HY-104061	AMG8788	Antagonist	/	Unkown
HY-104062	AMG9678	Antagonist	/	Unkown
HY-108461	TRPM8-IN-1	Inhibitor	/	Unkown
HY-15056	AMG 9090	Agonist	/	Unkown
HY-RS15118	TRPM8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N1369S1	Menthol-d2	Modulator	/	Unkown
HY-N9484S	Menthofuran-13C2		/	Unkown
HY-RS16771	Trpm8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23211	Trpm8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpm8	NCBI	NCBI:79054

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