Smad1 - SMAD family member 1 Gene

Mus musculus

Also known as Mad1; Mlp1; Madh1; Madr1; dwf-A; mMad1; MusMLP

Gene ID: 17125 | Gene type: protein coding

About Smad1

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and nucleic acid binding activity. Involved in several processes, including osteoblast differentiation; positive regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including animal organ development; osteoblast fate commitment; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human SMAD1 (Smad Family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Smad1 Products(1)

mRNA	Protein	Name
NM_008539.4	NP_032565.2	mothers against decapentaplegic homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14633973	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21976273	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18692037	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	21724602	MGI
enables primary miRNA binding	IDA IDA: Inferred from direct assay	21145505	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12370310	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23169531	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	25100727	MGI
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	21976273	MGI
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	16604073	MGI
involved in BMP signaling pathway	IGI IGI: Inferred from genetic interaction	19252488	MGI
acts upstream of or within BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	15198985	MGI
acts upstream of or within MAPK cascade	IMP IMP: Inferred from mutant phenotype	15198985	MGI
involved in SMAD protein signal transduction	IGI IGI: Inferred from genetic interaction	19252488	MGI
acts upstream of or within bone development	IGI IGI: Inferred from genetic interaction	19224984	MGI
acts upstream of or within cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	17350578	MGI
acts upstream of or within cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17350578	MGI
acts upstream of or within cartilage development	IGI IGI: Inferred from genetic interaction	19224984	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15899870	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19103752	MGI
acts upstream of or within gamete generation	IMP IMP: Inferred from mutant phenotype	15198985	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	15899870	MGI
acts upstream of or within homeostatic process	IMP IMP: Inferred from mutant phenotype	15198985	MGI
involved in inflammatory response	IEP IEP: Inferred from expression pattern	12151307	MGI
acts upstream of or within mesodermal cell fate commitment	IGI IGI: Inferred from genetic interaction	16801560	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	15899870	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15899870	MGI
involved in negative regulation of muscle cell differentiation	IDA IDA: Inferred from direct assay	21976273	MGI
involved in osteoblast differentiation	IDA IDA: Inferred from direct assay	7798324	MGI
acts upstream of or within osteoblast fate commitment	IGI IGI: Inferred from genetic interaction	15150273	MGI
acts upstream of or within positive regulation of cartilage development	IDA IDA: Inferred from direct assay	19251704	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18622394	MGI
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	21145505	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	15150273	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15557274	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24211589	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20843790	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	34995814	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	18776146	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12270938	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18997172	MGI
involved in ureteric bud development	IEP IEP: Inferred from expression pattern	14656760	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11160896	MGI
part of homomeric SMAD protein complex	IPI IPI: Inferred from physical interaction	20147459	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	21976273	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12151307	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	14633973	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mothers against decapentaplegic homolog 1

MAD homolog 1	dwarfin-A
mad-related protein 1	mothers against DPP homolog 1
mothers-against-DPP-related 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145608	Zilurgisertib	Inhibitor	98.25%	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99359	Elezanumab	Inhibitor	99.91%	Phase 2
HY-P99353	Ascrinvacumab	Inhibitor	97.45%	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-108527	CD1530		98.01%	Unkown
HY-12274	ML347	Inhibitor	99.94%	Unkown
HY-164145	CDD-1653		99.38%	Unkown
HY-123900	AZ12799734	Inhibitor	98.67%	Unkown
HY-148234	M4K2234	Inhibitor	98.31%	Unkown
HY-N0946	(-)-Pinoresinol 4-O-glucoside	Inhibitor	≥98.0%	Unkown
HY-173149	CDD-2789	Inhibitor	/	Unkown
HY-174416	Smurf1-IN-5	Inhibitor	/	Unkown
HY-RS05279	GARS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13392	SMAD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18190	Smad1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24664	Smad1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smad1	NCBI	NCBI:4086

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