Mlxipl - MLX interacting protein-like Gene

Rattus norvegicus

Also known as ChREBP; WS-bHLH; Wbscr14; bHLHd14

Gene ID: 171078 | Gene type: protein coding

About Mlxipl

Summary

Enables DNA-binding transcription factor activity; protein kinase binding activity; and sequence-specific DNA binding activity. Involved in several processes, including energy homeostasis; fatty acid homeostasis; and regulation of nucleobase-containing compound metabolic process. Located in cytosol and nucleus. Orthologous to human MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Apr 2022]

Mlxipl Products(2)

mRNA	Protein	Name
NM_001393706.1	NP_001380635.1	carbohydrate-responsive element-binding protein isoform 1
NM_133552.2	NP_598236.2	carbohydrate-responsive element-binding protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11724780	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11724780	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20025850	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11724780	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11724780	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	20025850	RGD
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	11724780	RGD
involved in fatty acid homeostasis	IMP IMP: Inferred from mutant phenotype	11724780	RGD
involved in regulation of glycolytic process	IDA IDA: Inferred from direct assay	11724780	RGD
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11724780	RGD
involved in response to glucose	IDA IDA: Inferred from direct assay	11470916	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	26394137	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	25943649	RGD
involved in response to vitamin B3	IEP IEP: Inferred from expression pattern	19878707	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	20025850	RGD
located in nucleus	IDA IDA: Inferred from direct assay	20025850	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

carbohydrate-responsive element-binding protein

MLX interactor	WS basic-helix-loop-helix leucine zipper protein
Williams-Beuren syndrome chromosomal region 14 protein	Williams-Beuren syndrome chromosome region 14 homolog
class D basic helix-loop-helix protein 14

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08505	MLXIPL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21156	Mlxipl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27672	Mlxipl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mlxipl	NCBI	NCBI:51085

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