Lrp6 - low density lipoprotein receptor-related protein 6 Gene

Mus musculus

Also known as Cd; Gw; ska26; skax26; ska; C030016K15Rik

Gene ID: 16974 | Gene type: protein coding

About Lrp6

Summary

Enables Wnt-protein binding activity; Apolipoprotein binding activity; and toxin transmembrane transporter activity. Involved in cell surface receptor signaling pathway involved in cell-cell signaling; positive regulation of neuron projection development; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of Wnt signaling pathway, planar cell polarity pathway. Located in early endosome and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study fatty liver disease and neural tube defect. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Apr 2022]

Lrp6 Products(1)

mRNA	Protein	Name
NM_008514.4	NP_032540.2	low-density lipoprotein receptor-related protein 6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	18606138	MGI
enables apolipoprotein binding	IPI IPI: Inferred from physical interaction	18948618	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12573468	MGI
enables toxin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	16564009	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Norrin signaling pathway	IDA IDA: Inferred from direct assay	15035989	MGI
acts upstream of or within Wnt signaling pathway involved in forebrain neuroblast division	IGI IGI: Inferred from genetic interaction	14715945	MGI
acts upstream of or within Wnt signaling pathway involved in forebrain neuroblast division	IMP IMP: Inferred from mutant phenotype	16920270	MGI
acts upstream of or within Wnt signaling pathway involved in somitogenesis	IMP IMP: Inferred from mutant phenotype	15469977	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	16126904	MGI
acts upstream of or within axis elongation	IMP IMP: Inferred from mutant phenotype	19795512	MGI
acts upstream of or within axis elongation involved in somitogenesis	IGI IGI: Inferred from genetic interaction	11029008	MGI
acts upstream of or within bone remodeling	IGI IGI: Inferred from genetic interaction	15537447	MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	19503830	MGI
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	11029008	MGI
acts upstream of or within canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19705442	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15064719	MGI
acts upstream of cardiac muscle tissue morphogenesis	IGI IGI: Inferred from genetic interaction	19056682	MGI
acts upstream of or within cell migration involved in gastrulation	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within cerebellum morphogenesis	IMP IMP: Inferred from mutant phenotype	11029008	MGI
acts upstream of or within cerebral cortex cell migration	IMP IMP: Inferred from mutant phenotype	16920270	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	16920270	MGI
acts upstream of or within convergent extension	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	19795519	MGI
acts upstream of or within dorsal/ventral axis specification	IMP IMP: Inferred from mutant phenotype	18985738	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	18985738	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	19795512	MGI
acts upstream of or within embryonic forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	15880584	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	11029008	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	15880584	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	19653321	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	20359476	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	19653321	MGI
acts upstream of or within embryonic retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	19653321	MGI
acts upstream of or within establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	25083995	MGI
acts upstream of or within establishment of blood-retinal barrier	IMP IMP: Inferred from mutant phenotype	25083995	MGI
acts upstream of or within external genitalia morphogenesis	IMP IMP: Inferred from mutant phenotype	19653321	MGI
acts upstream of or within face morphogenesis	IMP IMP: Inferred from mutant phenotype	19653321	MGI
acts upstream of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	17888405	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15384171	MGI
acts upstream of or within forebrain generation of neurons	IMP IMP: Inferred from mutant phenotype	14715945	MGI
acts upstream of or within forebrain radial glial cell differentiation	IGI IGI: Inferred from genetic interaction	14715945	MGI
acts upstream of or within formation of radial glial scaffolds	IGI IGI: Inferred from genetic interaction	14715945	MGI
acts upstream of or within gastrulation with mouth forming second	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within generation of neurons	IMP IMP: Inferred from mutant phenotype	15342729	MGI
acts upstream of or within heart looping	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of or within limb morphogenesis	IGI IGI: Inferred from genetic interaction	15537447	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	15469977	MGI
acts upstream of or within mammary gland duct morphogenesis	IGI IGI: Inferred from genetic interaction	19503830	MGI
acts upstream of or within mammary placode formation	IMP IMP: Inferred from mutant phenotype	19503830	MGI
acts upstream of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	19700620	MGI
acts upstream of or within mesodermal cell migration	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	11029008	MGI
acts upstream of or within midbrain-hindbrain boundary development	IMP IMP: Inferred from mutant phenotype	11029008	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19700620	MGI
acts upstream of or within negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	17888405	MGI
acts upstream of or within negative regulation of non-canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19056682	MGI
acts upstream of neural tube closure	IGI IGI: Inferred from genetic interaction	19056682	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	10545599	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	591875	MGI
acts upstream of outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	19056682	MGI
acts upstream of pericardium morphogenesis	IGI IGI: Inferred from genetic interaction	19056682	MGI
acts upstream of or within pericardium morphogenesis	IGI IGI: Inferred from genetic interaction	19795512	MGI
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	15035989	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15035989	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19700620	MGI
acts upstream of or within positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	18505367	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	19700620	MGI
involved in positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	23845000	MGI
acts upstream of or within positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	15469977	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	19700620	MGI
acts upstream of or within post-anal tail morphogenesis	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	19653321	MGI
acts upstream of or within primitive streak formation	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of or within receptor-mediated endocytosis involved in cholesterol transport	IMP IMP: Inferred from mutant phenotype	18948618	MGI
acts upstream of or within regulation of cell development	IMP IMP: Inferred from mutant phenotype	19795519	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	591875	MGI
acts upstream of or within response to folic acid	IMP IMP: Inferred from mutant phenotype	17050573	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	18985738	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	19653321	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	15469977	MGI
acts upstream of or within somitogenesis	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	19700620	MGI
acts upstream of or within thalamus development	IMP IMP: Inferred from mutant phenotype	15342729	MGI
acts upstream of or within trachea cartilage morphogenesis	IGI IGI: Inferred from genetic interaction	18256198	MGI
acts upstream of ventricular septum morphogenesis	IGI IGI: Inferred from genetic interaction	19056682	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	18948618	MGI
located in membrane	IDA IDA: Inferred from direct assay	16126904	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18505367	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low-density lipoprotein receptor-related protein 6

LRP-6	crooked
low density lipoprotein receptor-related protein 6	low density lipoprotein-related protein 6
low density lipoprotein-related protein 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17439	Salinomycin sodium salt		99.81%	Yes
HY-15597	Salinomycin		99.66%	Yes
HY-122816	HLY78		98.44%	Unkown
HY-D0961	Gallocyanine chloride	Activator	92.00%	Unkown
HY-100853	IWP-O1	Inhibitor	99.81%	Unkown
HY-RS16293	Lrp6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-160709	Wnt/β-catenin-IN-2	Inhibitor	/	Unkown
HY-E70390	C1s Enzyme	Antagonist	/	Unkown
HY-RS07801	LRP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23672	Lrp6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991311	GSK3178022	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrp6	NCBI	NCBI:4040

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