2. Gene
  3. Lig1 - ligase I, DNA, ATP-dependent Gene

Lig1 - ligase I, DNA, ATP-dependent Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as LigI

Gene ID: 16881 | Gene type: protein coding

About Lig1

Summary

Predicted to enable DNA Ligase (ATP) activity. Acts upstream of or within DNA replication; double-strand break repair via nonhomologous end joining; and response to hydrogen peroxide. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Lig1 Products(3)

mRNA Protein Name
NM_001083188.2 NP_001076657.2 DNA ligase 1
NM_001199310.2 NP_001186239.2 DNA ligase 1
NM_010715.3 NP_034845.3 DNA ligase 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
NOT acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
11896201 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
21390131 MGI
acts upstream of or within DNA replication IMP
IMP: Inferred from mutant phenotype
11896201 MGI
acts upstream of or within double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
21655080 MGI
acts upstream of or within response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
21390131 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
9001252 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA ligase 1

DNA ligase I

polydeoxyribonucleotide synthase [ATP] 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15587 L82 Inhibitor 98.89% Unkown
HY-161152 DNA relaxation-IN-1 Inhibitor 99.37% Unkown
HY-RS07642 LIG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18139 Lig1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24614 Lig1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W004883 3-Amino-4,6-dimethylpyridine Inhibitor 99.87% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lig1 NCBI NCBI:3978
Macaca fascicularis Lig1 NCBI NCBI:101864859