Khk - ketohexokinase Gene

Mus musculus

Gene ID: 16548 | Gene type: protein coding

About Khk

Summary

Enables Ketohexokinase activity. Acts upstream of or within fructose metabolic process and regulation of glycogen metabolic process. Located in cytoplasm and nucleus. Is expressed in alimentary system; central nervous system; liver; and retina. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (Ketohexokinase). [provided by Alliance of Genome Resources, Apr 2022]

Khk Products(4)

mRNA	Protein	Name
NM_001310524.1	NP_001297453.1	ketohexokinase isoform 1
NM_001310525.1	NP_001297454.1	ketohexokinase isoform 3
NM_001349066.1	NP_001335995.1	ketohexokinase isoform 4
NM_008439.4	NP_032465.2	ketohexokinase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ketohexokinase activity	IDA IDA: Inferred from direct assay	15652177	MGI
enables ketohexokinase activity	IMP IMP: Inferred from mutant phenotype	28194018	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in fructose catabolic process	IDA IDA: Inferred from direct assay	4343087	MGI
involved in fructose catabolic process	IMP IMP: Inferred from mutant phenotype	23813872	MGI
involved in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	IMP IMP: Inferred from mutant phenotype	23813872	MGI
acts upstream of or within fructose metabolic process	IMP IMP: Inferred from mutant phenotype	22371574	MGI
acts upstream of or within regulation of glycogen metabolic process	IMP IMP: Inferred from mutant phenotype	22371574	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19365088	MGI
is active in cytosol	IDA IDA: Inferred from direct assay	26851500	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19365088	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ketohexokinase

hepatic fructokinase

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17613	Evocalcet	Activator	98.39%	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9925	Brodalumab	Inhibitor	99.18%	Unkown
HY-P9923	Benralizumab		≥99.1%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99955	Rocatinlimab		99.95%	Phase 3

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12841A	KHK-IN-1 hydrochloride	Inhibitor	98.47%	Unkown
HY-103478	KHK-IN-2	Inhibitor	99.05%	Unkown
HY-149987	LY3522348	Inhibitor	98.30%	Unkown
HY-U00461	PF-06835919	Inhibitor	99.75%	Unkown
HY-12841	KHK-IN-1	Inhibitor	/	Unkown
HY-159123	KHK-6	Inhibitor	/	Unkown
HY-RS07240	KHK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-149605	KHK-IN-4	Inhibitor	/	Unkown
HY-162982	KHK-IN-6		/	Unkown
HY-163886	KHK-IN-5	Inhibitor	/	Unkown
HY-172610	KHK-IN-7	Inhibitor	/	Unkown
HY-17613S	Evocalcet-d4	Activator	/	Unkown
HY-RS17728	Khk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24193	Khk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991282	KHK2823	Inhibitor	/	Unkown
HY-P991536	KHK6640	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Khk	NCBI	NCBI:3795

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