Ush1g - USH1 protein network component sans Gene

Mus musculus

Also known as js; Sans

Gene ID: 16470 | Gene type: protein coding

About Ush1g

Summary

This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with combined auditory and vision loss. [provided by RefSeq, Sep 2015]

Ush1g Products(1)

mRNA	Protein	Name
NM_176847.3	NP_789817.1	pre-mRNA splicing regulator USH1G

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15590703	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15590703	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	1927362	MGI
acts upstream of or within inner ear receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	1442008	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	18339676	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	1927362	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	12588794	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	17906286	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15590703	MGI
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	17906286	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	17906286	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pre-mRNA splicing regulator USH1G

Usher syndrome type-1G protein homolog

Usher syndrome 1G homolog	jackson shaker protein
scaffold protein containing ankyrin repeats and SAM domain	scaffold protein, amkyrin repeats and SAM domain containing
scaffold protein, ankyrin repeats and SAM domain containing	usher syndrome type-1G

Ush1g Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ush1g	Q80T11	Myo7a	Mus musculus	P97479	Pull Down	15590703
Intra	Ush1g	Q80T11	Ush1c	Mus musculus	Q9ES64-3	Pull Down	15590703

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15517	USH1G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22898	Ush1g Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ush1g	NCBI	NCBI:124590

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