Itpr3 - inositol 1,4,5-triphosphate receptor 3 Gene

Mus musculus

Also known as tf; Ip3r3; IP3R 3; Itpr-3

Gene ID: 16440 | Gene type: protein coding

About Itpr3

Summary

Enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in calcium ion transport into cytosol. Acts upstream of or within several processes, including long-term synaptic potentiation; memory; and sensory perception of taste. Located in endoplasmic reticulum membrane; nucleolus; and nucleoplasm. Is expressed in several structures, including jaw; liver; sensory organ; skeleton; and spleen. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Apr 2022]

Itpr3 Products(1)

mRNA	Protein	Name
NM_080553.3	NP_542120.2	inositol 1,4,5-trisphosphate receptor type 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IDA IDA: Inferred from direct assay	9065779	MGI
enables intracellularly gated calcium channel activity	IDA IDA: Inferred from direct assay	20813840	MGI
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	17327232	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16352659	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion transport	IDA IDA: Inferred from direct assay	15890645	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	18417102	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	18417102	MGI
acts upstream of or within sensory perception of bitter taste	IMP IMP: Inferred from mutant phenotype	17925404	MGI
acts upstream of or within sensory perception of sweet taste	IMP IMP: Inferred from mutant phenotype	17925404	MGI
acts upstream of or within sensory perception of umami taste	IMP IMP: Inferred from mutant phenotype	17925404	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16014380	MGI
located in cytoplasmic side of endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21030605	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	16014380	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	16014380	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16014380	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

inositol 1,4,5-trisphosphate receptor type 3

IP3 receptor	insP3R3
type 3 InsP3 receptor	type 3 inositol 1,4,5-trisphosphate receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06993	ITPR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21604	Itpr3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itpr3	NCBI	NCBI:3710

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