Isl1 - ISL1 transcription factor, LIM/homeodomain Gene

Mus musculus

Gene ID: 16392 | Gene type: protein coding

About Isl1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including heart development; nervous system development; and positive regulation of cytokine production. Acts upstream of or within several processes, including animal organ development; neuron development; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Isl1 Products(1)

mRNA	Protein	Name
NM_021459.4	NP_067434.3	insulin gene enhancer protein ISL-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19620969	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15659653	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18434421	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	24643061	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9192866	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24643061	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18539116	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in atrial septum morphogenesis	IGI IGI: Inferred from genetic interaction	17519333	MGI
acts upstream of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19620969	MGI
acts upstream of or within cardiac cell fate determination	IMP IMP: Inferred from mutant phenotype	19620969	MGI
acts upstream of or within cardiac muscle cell myoblast differentiation	IMP IMP: Inferred from mutant phenotype	19620969	MGI
involved in cardiac right ventricle morphogenesis	IGI IGI: Inferred from genetic interaction	17519333	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	15659653	MGI
involved in endocardial cushion morphogenesis	IGI IGI: Inferred from genetic interaction	17519333	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	14667410	MGI
acts upstream of or within heart morphogenesis	IGI IGI: Inferred from genetic interaction	16687132	MGI
involved in innervation	IMP IMP: Inferred from mutant phenotype	18849985	MGI
acts upstream of or within mesenchymal cell differentiation	IMP IMP: Inferred from mutant phenotype	9000074	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19620969	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	22727192	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18849985	MGI
acts upstream of or within negative regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	14766174	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18849985	MGI
acts upstream of or within neural crest cell migration	IGI IGI: Inferred from genetic interaction	16687132	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	14766174	MGI
acts upstream of or within neuron differentiation	IGI IGI: Inferred from genetic interaction	18434416	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	8565076	MGI
acts upstream of or within neuron fate commitment	IGI IGI: Inferred from genetic interaction	14766174	MGI
involved in neuron fate specification	IMP IMP: Inferred from mutant phenotype	18849985	MGI
involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	17519333	MGI
involved in outflow tract septum morphogenesis	IGI IGI: Inferred from genetic interaction	17519333	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	9000074	MGI
involved in peripheral nervous system neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	18849985	MGI
acts upstream of or within peripheral nervous system neuron development	IGI IGI: Inferred from genetic interaction	21734270	MGI
involved in pharyngeal system development	IGI IGI: Inferred from genetic interaction	17519333	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	9806931	MGI
acts upstream of or within positive regulation of DNA binding	IDA IDA: Inferred from direct assay	15659653	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	22727192	MGI
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	25775587	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15659653	MGI
involved in positive regulation of granulocyte colony-stimulating factor production	IDA IDA: Inferred from direct assay	22727192	MGI
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	22727192	MGI
involved in positive regulation of interleukin-1 alpha production	IDA IDA: Inferred from direct assay	22727192	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	22727192	MGI
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	22727192	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	22727192	MGI
involved in positive regulation of macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	22727192	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19620969	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18434421	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14664703	MGI
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	22727192	MGI
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	22727192	MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	15659653	MGI
involved in positive regulation of vascular endothelial growth factor production	IDA IDA: Inferred from direct assay	22727192	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19666821	MGI
acts upstream of regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	26193633	MGI
acts upstream of or within regulation of secondary heart field cardioblast proliferation	IMP IMP: Inferred from mutant phenotype	19620969	MGI
acts upstream of or within retinal ganglion cell axon guidance	IMP IMP: Inferred from mutant phenotype	18434421	MGI
involved in sensory system development	IMP IMP: Inferred from mutant phenotype	18849985	MGI
involved in sinoatrial node cell development	IMP IMP: Inferred from mutant phenotype	26193633	MGI
acts upstream of or within spinal cord motor neuron cell fate specification	IGI IGI: Inferred from genetic interaction	19666821	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	8565076	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	9000074	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22343712	MGI
involved in trigeminal nerve development	IMP IMP: Inferred from mutant phenotype	18849985	MGI
involved in ventricular cardiac muscle tissue morphogenesis	IGI IGI: Inferred from genetic interaction	17519333	MGI
acts upstream of or within visceral motor neuron differentiation	IGI IGI: Inferred from genetic interaction	14766174	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	18539116	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10536059	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulin gene enhancer protein ISL-1

Islet 1	Lim-homeodomain protein Islet1
insulin related protein	islet-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06931	ISL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18481	Isl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24962	Isl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Isl1	NCBI	NCBI:3670

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