Ighm - immunoglobulin heavy constant mu Gene

Mus musculus

Also known as Igm; muH; Igh6; Igh-6; Igh-M

Gene ID: 16019 | Gene type: other

About Ighm

Summary

Enables several functions, including antigen binding activity; identical protein binding activity; and immunoglobulin receptor binding activity. Acts upstream of or within several processes, including early endosome to late endosome transport; immunoglobulin mediated immune response; and positive regulation of B cell proliferation. Located in external side of plasma membrane; extracellular space; and perinuclear region of cytoplasm. Part of B cell receptor complex and immunoglobulin complex, circulating. Is expressed in several structures, including brain; hemolymphoid system; and liver. Used to study non-Hodgkin lymphoma and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in agammaglobulinemia. Orthologous to human IGHM (immunoglobulin heavy constant mu). [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables antigen binding	IDA IDA: Inferred from direct assay	7688139	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	24963139	MGI
enables immunoglobulin receptor binding	IPI IPI: Inferred from physical interaction	20031218	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	1373499	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	1373499	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell activation	IDA IDA: Inferred from direct assay	8566034	MGI
acts upstream of or within B cell affinity maturation	IMP IMP: Inferred from mutant phenotype	9707605	MGI
acts upstream of B cell proliferation	IDA IDA: Inferred from direct assay	8666928	MGI
acts upstream of or within B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	1373499	MGI
acts upstream of MAPK cascade	IDA IDA: Inferred from direct assay	9254656	MGI
acts upstream of or within humoral immune response mediated by circulating immunoglobulin	IDA IDA: Inferred from direct assay	8041705	MGI
acts upstream of or within immunoglobulin mediated immune response	IDA IDA: Inferred from direct assay	8552190	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7499277	MGI
acts upstream of or within positive regulation of B cell activation	IDA IDA: Inferred from direct assay	8566034	MGI
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	8552190	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	9254656	MGI
acts upstream of or within positive regulation of immune response	IMP IMP: Inferred from mutant phenotype	9707605	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	1373499	MGI
involved in pre-B cell allelic exclusion	IMP IMP: Inferred from mutant phenotype	1545868	MGI
acts upstream of or within regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	9707605	MGI
acts upstream of or within regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	9707605	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of B cell receptor complex	IDA IDA: Inferred from direct assay	1373499	MGI
located in cell surface	IDA IDA: Inferred from direct assay	9707605	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	28923960	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	1373499	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	9707605	MGI
part of immunoglobulin complex, circulating	IDA IDA: Inferred from direct assay	7688139	MGI
located in membrane	IDA IDA: Inferred from direct assay	9707605	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	1373499	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16457	IGHM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22206	Ighm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28728	Gcnt4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ighm	NCBI	NCBI:3507

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