2. Gene
  3. Hsd11b1 - hydroxysteroid 11-beta dehydrogenase 1 Gene

Hsd11b1 - hydroxysteroid 11-beta dehydrogenase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 15483 | Gene type: protein coding

About Hsd11b1

Summary

Enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity. Acts upstream of or within lung development. Predicted to be located in apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study cortisone reductase deficiency 2. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 2; and obesity. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsd11b1 Products(2)

mRNA Protein Name
NM_001044751.1 NP_001038216.1 11-beta-hydroxysteroid dehydrogenase 1
NM_008288.2 NP_032314.2 11-beta-hydroxysteroid dehydrogenase 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
8940387 MGI
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IMP
IMP: Inferred from mutant phenotype
12439781 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12439781 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

11-beta-hydroxysteroid dehydrogenase 1

corticosteroid 11-beta-dehydrogenase isozyme 1

11-DH

11-beta-HSD1

11-beta-HSD1A/MCR

11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase

11beta-HSD-1

11beta-HSD1A

11beta-hydroxysteroid dehydrogenase type 1

7-oxosteroid reductase

Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06387 HSD11B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-167696 11β-HSD1-IN-16 Inhibitor / Unkown
HY-RS20631 Hsd11b1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27140 Hsd11b1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd11b1 NCBI NCBI:3290