Hoxd10 - homeobox D10 Gene

Mus musculus

Also known as Hox-4.5; Hox-5.3

Gene ID: 15430 | Gene type: protein coding

About Hoxd10

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including limb morphogenesis; neuron differentiation; and regionalization. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and limb bud. Human ortholog(s) of this gene implicated in congenital vertical talus. Orthologous to human HOXD10 (homeobox D10). [provided by Alliance of Genome Resources, Apr 2022]

Hoxd10 Products(1)

mRNA	Protein	Name
NM_013554.5	NP_038582.2	homeobox protein Hox-D10

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1756725	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11432851	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	1756725	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11432851	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16672333	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14973489	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult locomotory behavior	IGI IGI: Inferred from genetic interaction	10642795	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	10642795	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	12869760	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	10642795	MGI
acts upstream of or within forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	10642795	MGI
acts upstream of or within hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	10642795	MGI
acts upstream of or within neuromuscular process	IGI IGI: Inferred from genetic interaction	18065432	MGI
acts upstream of or within peripheral nervous system neuron development	IGI IGI: Inferred from genetic interaction	10642795	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1756725	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11432851	MGI
acts upstream of or within proximal/distal pattern formation	IGI IGI: Inferred from genetic interaction	12869760	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	23760953	MGI
acts upstream of or within single fertilization	IGI IGI: Inferred from genetic interaction	23760953	MGI
acts upstream of or within skeletal muscle tissue development	IGI IGI: Inferred from genetic interaction	10642795	MGI
acts upstream of or within skeletal system development	IGI IGI: Inferred from genetic interaction	12869760	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	9409668	MGI
acts upstream of or within spinal cord motor neuron cell fate specification	IGI IGI: Inferred from genetic interaction	18065432	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Hox-D10

homeo box D10	homeobox protein Hox-4.5
homeobox protein Hox-5.3

Hoxd10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Hoxd10	P28359	Gmnn	Mus musculus	O88513	Y2H	14973489

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06323	HOXD10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hoxd10	NCBI	NCBI:3236

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