Foxa2 - forkhead box A2 Gene

Mus musculus

Also known as Hnf3b; Tcf3b; Hnf-3b; Tcf-3b; HNF3beta; HNF3-beta

Gene ID: 15376 | Gene type: protein coding

About Foxa2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of detection of glucose; negative regulation of Glucokinase activity; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of neuron differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; endoderm; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2). [provided by Alliance of Genome Resources, Apr 2022]

Foxa2 Products(3)

mRNA	Protein	Name
NM_001291065.1	NP_001277994.1	hepatocyte nuclear factor 3-beta isoform a
NM_001291067.1	NP_001277996.1	hepatocyte nuclear factor 3-beta isoform c
NM_010446.3	NP_034576.2	hepatocyte nuclear factor 3-beta isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11875061	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11914369	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10859308	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11875061	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12488434	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22780989	MGI
enables double-stranded DNA binding	IGI IGI: Inferred from genetic interaction	23117660	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20609350	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11914369	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	18076286	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IGI IGI: Inferred from genetic interaction	10498685	MGI
acts upstream of or within anatomical structure morphogenesis	IGI IGI: Inferred from genetic interaction	9226455	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	10498685	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	15680365	MGI
acts upstream of or within cell differentiation in hindbrain	IGI IGI: Inferred from genetic interaction	17922007	MGI
acts upstream of or within cell differentiation in hindbrain	IMP IMP: Inferred from mutant phenotype	17922007	MGI
acts upstream of or within cell fate specification	IDA IDA: Inferred from direct assay	18076286	MGI
acts upstream of or within cellular response to cadmium ion	IDA IDA: Inferred from direct assay	15219627	MGI
acts upstream of or within connective tissue development	IGI IGI: Inferred from genetic interaction	23383217	MGI
acts upstream of dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	17596284	MGI
acts upstream of dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	17596284	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	18076286	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IDA IDA: Inferred from direct assay	18590716	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IGI IGI: Inferred from genetic interaction	9226455	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	10498685	MGI
acts upstream of or within ectoderm formation	IGI IGI: Inferred from genetic interaction	10498685	MGI
acts upstream of or within endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	15680365	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IGI IGI: Inferred from genetic interaction	15668254	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	29659575	MGI
involved in glucose mediated signaling pathway	IDA IDA: Inferred from direct assay	11875061	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9152011	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	15668254	MGI
acts upstream of or within lung epithelial cell differentiation	IGI IGI: Inferred from genetic interaction	15668254	MGI
acts upstream of mesendoderm development	IMP IMP: Inferred from mutant phenotype	26494787	MGI
acts upstream of or within negative regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	17922007	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11875061	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	17596284	MGI
acts upstream of or within neuron differentiation	IGI IGI: Inferred from genetic interaction	17922007	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	17596284	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	17922007	MGI
acts upstream of or within neuron fate specification	IGI IGI: Inferred from genetic interaction	17596284	MGI
acts upstream of or within neuron fate specification	IMP IMP: Inferred from mutant phenotype	17922007	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	10498685	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11291865	MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	17596284	MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	17596284	MGI
involved in positive regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in positive regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	11291865	MGI
acts upstream of or within positive regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	17922007	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	23383217	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10859308	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11875061	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15539431	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9152011	MGI
involved in positive regulation of transcription by RNA polymerase III	IMP IMP: Inferred from mutant phenotype	15737987	MGI
acts upstream of or within primitive streak formation	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in primitive streak formation	IMP IMP: Inferred from mutant phenotype	11291865	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12488434	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	17596284	MGI
involved in regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	11875061	MGI
acts upstream of or within regulation of lipid metabolic process	IDA IDA: Inferred from direct assay	22737085	MGI
acts upstream of or within regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	22737085	MGI
acts upstream of or within regulation of steroid metabolic process	IDA IDA: Inferred from direct assay	22737085	MGI
acts upstream of or within regulation of steroid metabolic process	IMP IMP: Inferred from mutant phenotype	22737085	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	23383217	MGI
acts upstream of or within somite rostral/caudal axis specification	IMP IMP: Inferred from mutant phenotype	11291865	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10859308	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8813084	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	26494787	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 3-beta

HNF-3-beta	forkhead box protein A2
hepatocyte nuclear factor 3 beta (winged helix transcription factor)

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05037	FOXA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18820	Foxa2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25310	Foxa2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxa2	NCBI	NCBI:3170

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