Foxa1 - forkhead box A1 Gene

Mus musculus

Also known as Hnf3a; Tcf3a; Hnf-3a; Tcf-3a

Gene ID: 15375 | Gene type: protein coding

About Foxa1

Summary

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including lung development; prostate gland development; and regulation of transcription by RNA polymerase II. Located in microvillus and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FOXA1 (forkhead box A1). [provided by Alliance of Genome Resources, Apr 2022]

Foxa1 Products(1)

mRNA	Protein	Name
NM_008259.4	NP_032285.2	hepatocyte nuclear factor 3-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15485926	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10049364	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10049364	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22780989	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8306889	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within alveolar secondary septum development	IMP IMP: Inferred from mutant phenotype	16214823	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IGI IGI: Inferred from genetic interaction	23383217	MGI
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	15748903	MGI
acts upstream of or within connective tissue development	IGI IGI: Inferred from genetic interaction	23383217	MGI
acts upstream of dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	17596284	MGI
acts upstream of dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	17596284	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IGI IGI: Inferred from genetic interaction	23383217	MGI
acts upstream of or within epithelial cell maturation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	15987773	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IGI IGI: Inferred from genetic interaction	15668254	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	10049364	MGI
acts upstream of or within hormone metabolic process	IMP IMP: Inferred from mutant phenotype	10049364	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	15668254	MGI
acts upstream of or within lung epithelial cell differentiation	IGI IGI: Inferred from genetic interaction	15668254	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	16214823	MGI
acts upstream of or within mesenchymal-epithelial cell signaling involved in prostate gland development	IGI IGI: Inferred from genetic interaction	15987773	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17220277	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	17596284	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	17596284	MGI
acts upstream of or within neuron fate specification	IGI IGI: Inferred from genetic interaction	17596284	MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	17596284	MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	17596284	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	23383217	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10049364	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15539431	MGI
acts upstream of or within prostate gland epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	15987773	MGI
acts upstream of or within prostate gland stromal morphogenesis	IMP IMP: Inferred from mutant phenotype	15987773	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	22737085	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	22737085	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	17596284	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16214823	MGI
acts upstream of or within respiratory basal cell differentiation	IMP IMP: Inferred from mutant phenotype	16214823	MGI
acts upstream of or within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	IMP IMP: Inferred from mutant phenotype	15987773	MGI
acts upstream of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	23383217	MGI
acts upstream of or within tube morphogenesis	IMP IMP: Inferred from mutant phenotype	15987773	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in microvillus	IDA IDA: Inferred from direct assay	23266329	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8306889	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 3-alpha

HNF-3-alpha	fork head domain
forkhead box protein A1	hepatocyte nuclear factor 3 alpha (winged helix transcription factor)

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156190A	NR2F2-IN-1 free base	Inhibitor	99.34%	Unkown
HY-168534	WX-02-23		99.88%	Unkown
HY-RS05036	FOXA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-156190	NR2F2-IN-1	Inhibitor	/	Unkown
HY-RS17339	Foxa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23794	Foxa1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxa1	NCBI	NCBI:3169

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