2. Gene
  3. Hmgcs2 - 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 Gene

Hmgcs2 - 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mHS; 1300002P16

Gene ID: 15360 | Gene type: protein coding

About Hmgcs2

Summary

Enables hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; and ketone body biosynthetic process. Predicted to act upstream of or within Cholesterol biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; facial bone primordium; nervous system; and reproductive system. Orthologous to human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcs2 Products(1)

mRNA Protein Name
NM_008256.4 NP_032282.2 hydroxymethylglutaryl-CoA synthase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables hydroxymethylglutaryl-CoA synthase activity IDA
IDA: Inferred from direct assay
24315375 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
26767982 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hydroxymethylglutaryl-CoA synthase, mitochondrial

3-hydroxy-3-methylglutaryl coenzyme A synthase

HMG-CoA synthase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06242 HMGCS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18424 Hmgcs2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24905 Hmgcs2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgcs2 NCBI NCBI:3158