Hes5 - hes family bHLH transcription factor 5 Gene

Mus musculus

Also known as bHLHb38

Gene ID: 15208 | Gene type: protein coding

About Hes5

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including nervous system development; positive regulation of signal transduction; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including nephron morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; paraxial mesenchyme; sensory organ; small intestine; and urinary system. Orthologous to human HES5 (hes family bHLH transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Hes5 Products(2)

mRNA	Protein	Name
NM_001370755.1	NP_001357684.1	transcription factor HES-5 isoform 2
NM_010419.4	NP_034549.1	transcription factor HES-5 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21259317	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15156153	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	18579678	MGI
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25535395	MGI
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	17331197	MGI
involved in S-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	15821257	MGI
involved in astrocyte differentiation	IDA IDA: Inferred from direct assay	15156153	MGI
involved in brain development	IMP IMP: Inferred from mutant phenotype	17331197	MGI
involved in camera-type eye development	IMP IMP: Inferred from mutant phenotype	17331197	MGI
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	17093926	MGI
acts upstream of or within cell adhesion	IGI IGI: Inferred from genetic interaction	15496443	MGI
acts upstream of or within cell maturation	IGI IGI: Inferred from genetic interaction	15496443	MGI
acts upstream of or within central nervous system myelination	IMP IMP: Inferred from mutant phenotype	17006542	MGI
NOT involved in chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17093926	MGI
involved in comma-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within establishment of epithelial cell polarity	IGI IGI: Inferred from genetic interaction	21300049	MGI
acts upstream of or within glial cell fate commitment	IMP IMP: Inferred from mutant phenotype	10821751	MGI
acts upstream of inner ear auditory receptor cell differentiation	IGI IGI: Inferred from genetic interaction	21300049	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IGI IGI: Inferred from genetic interaction	21300049	MGI
involved in metanephric nephron tubule morphogenesis	IEP IEP: Inferred from expression pattern	15465493	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12208538	MGI
involved in negative regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	12666205	MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation	IGI IGI: Inferred from genetic interaction	21300049	MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	11425898	MGI
involved in negative regulation of inner ear receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	12208538	MGI
acts upstream of or within negative regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	10205173	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	10205173	MGI
involved in negative regulation of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	12666205	MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17006542	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19050759	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17006542	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	10804175	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	10205173	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	10205173	MGI
involved in neuronal stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	11399758	MGI
acts upstream of or within oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	17006542	MGI
acts upstream of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17006542	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	18579678	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12208538	MGI
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	12208538	MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	15156153	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19050759	MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	15156153	MGI
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	15156153	MGI
acts upstream of or within regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	18048645	MGI
acts upstream of or within regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	21300049	MGI
acts upstream of or within regulation of myelination	IMP IMP: Inferred from mutant phenotype	17006542	MGI
acts upstream of or within regulation of neurogenesis	IGI IGI: Inferred from genetic interaction	10804175	MGI
acts upstream of or within regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	10804175	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: Inferred from direct assay	19124651	MGI
involved in specification of loop of Henle identity	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within telencephalon development	IGI IGI: Inferred from genetic interaction	18579678	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor HES-5

hairy and enhancer of split 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120782	Yhhu-3792	Activator	99.34%	Unkown
HY-120782A	Yhhu-3792 hydrochloride	Activator	/	Unkown
HY-RS06138	HES5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18944	Hes5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25434	Hes5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hes5	NCBI	NCBI:388585

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