Grin1 - glutamate receptor, ionotropic, NMDA1 (zeta 1) Gene

Mus musculus

Also known as NR1; GluN1; Nmdar; NMD-R1; NMDAR1; M100174; Rgsc174; GluRzeta1; GluRdelta1

Gene ID: 14810 | Gene type: protein coding

About Grin1

Summary

Enables several functions, including Calmodulin binding activity; cation binding activity; and ion channel activity. Involved in propylene metabolic process. Acts upstream of or within several processes, including chemical synaptic transmission; learning or memory; and regulation of neuron projection development. Located in several cellular components, including dendritic spine; postsynaptic density membrane; and synaptic vesicle membrane. Is integral component of postsynaptic density membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder and schizophrenia. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Grin1 Products(8)

mRNA	Protein	Name
NM_001177656.2	NP_001171127.1	glutamate receptor ionotropic, NMDA 1 isoform 2
NM_001177657.2	NP_001171128.1	glutamate receptor ionotropic, NMDA 1 isoform 3 precursor
NM_001372558.1	NP_001359487.1	glutamate receptor ionotropic, NMDA 1 isoform 4 precursor
NM_001372559.1	NP_001359488.1	glutamate receptor ionotropic, NMDA 1 isoform 5 precursor
NM_001372560.1	NP_001359489.1	glutamate receptor ionotropic, NMDA 1 isoform 6 precursor
NM_001372561.1	NP_001359490.1	glutamate receptor ionotropic, NMDA 1 isoform 7 precursor
NM_001372562.1	NP_001359491.1	glutamate receptor ionotropic, NMDA 1 isoform 8 precursor
NM_008169.3	NP_032195.1	glutamate receptor ionotropic, NMDA 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NMDA glutamate receptor activity	IDA IDA: Inferred from direct assay	1374164	MGI
enables NMDA glutamate receptor activity	IGI IGI: Inferred from genetic interaction	1374164	MGI
enables NMDA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	8060614	MGI
enables calcium channel activity	IDA IDA: Inferred from direct assay	1374164	MGI
enables calcium channel activity	IGI IGI: Inferred from genetic interaction	1374164	MGI
enables calcium ion binding	IDA IDA: Inferred from direct assay	15663482	MGI
enables calmodulin binding	IDA IDA: Inferred from direct assay	15663482	MGI
enables glycine binding	IMP IMP: Inferred from mutant phenotype	12586454	MGI
enables monoatomic cation channel activity	IGI IGI: Inferred from genetic interaction	7531804	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8595214	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11754835	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	10481908	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	12040087	MGI
acts upstream of or within calcium ion homeostasis	IDA IDA: Inferred from direct assay	7907365	MGI
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	1532151	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	15576450	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	10963597	MGI
acts upstream of or within conditioned taste aversion	IMP IMP: Inferred from mutant phenotype	16101757	MGI
acts upstream of or within excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	14645471	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	15003177	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	8060614	MGI
acts upstream of or within ionotropic glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	16025111	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	17015831	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	17004940	MGI
acts upstream of or within long-term memory	IMP IMP: Inferred from mutant phenotype	15003177	MGI
acts upstream of or within male mating behavior	IMP IMP: Inferred from mutant phenotype	10481908	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	10700255	MGI
acts upstream of or within monoatomic cation transport	IGI IGI: Inferred from genetic interaction	7531804	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	17077143	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17077143	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	8313466	MGI
acts upstream of or within neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	8060614	MGI
acts upstream of or within olfactory learning	IMP IMP: Inferred from mutant phenotype	10700255	MGI
acts upstream of or within pons maturation	IMP IMP: Inferred from mutant phenotype	8313466	MGI
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	17803966	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7907365	MGI
acts upstream of or within prepulse inhibition	IMP IMP: Inferred from mutant phenotype	15265649	MGI
involved in propylene metabolic process	IDA IDA: Inferred from direct assay	21795692	MGI
acts upstream of or within protein localization to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	12676993	MGI
acts upstream of or within regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	15745956	MGI
acts upstream of or within regulation of cell communication	IMP IMP: Inferred from mutant phenotype	16299502	MGI
acts upstream of or within regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	15745956	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	10818139	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	8060614	MGI
acts upstream of or within regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10479699	MGI
acts upstream of or within regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16906136	MGI
acts upstream of or within regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	15576450	MGI
acts upstream of or within regulation of respiratory gaseous exchange	IMP IMP: Inferred from mutant phenotype	8313466	MGI
acts upstream of or within regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	12657691	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	8980238	MGI
acts upstream of or within response to amphetamine	IGI IGI: Inferred from genetic interaction	21368124	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	15467708	MGI
acts upstream of or within response to morphine	IMP IMP: Inferred from mutant phenotype	18423864	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	12832526	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	10481908	MGI
acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	10818139	MGI
acts upstream of or within suckling behavior	IMP IMP: Inferred from mutant phenotype	8313466	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	8313466	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7907365	MGI
acts upstream of or within visual learning	IGI IGI: Inferred from genetic interaction	9054942	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	8980238	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NMDA selective glutamate receptor complex	IDA IDA: Inferred from direct assay	12008020	MGI
part of NMDA selective glutamate receptor complex	IPI IPI: Inferred from physical interaction	9003035	MGI
located in cell surface	IDA IDA: Inferred from direct assay	17229826	MGI
located in cell surface	IMP IMP: Inferred from mutant phenotype	17229826	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12414093	MGI
located in dendrite	IDA IDA: Inferred from direct assay	23395379	MGI
located in dendrite	IMP IMP: Inferred from mutant phenotype	17229826	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	15663482	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16814779	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19726645	MGI
located in membrane	IDA IDA: Inferred from direct assay	8840015	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	1532151	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	15317856	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	19726645	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	11754836	MGI
located in synapse	IDA IDA: Inferred from direct assay	14645471	MGI
located in synaptic membrane	IDA IDA: Inferred from direct assay	26041915	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	10846156	MGI
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	29490264	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, NMDA 1

N-methyl-D-aspartate receptor subunit NR1

glutamate [NMDA] receptor subunit zeta-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05803	GRIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20948	Grin1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27465	Grin1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grin1	NCBI	NCBI:2902

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