2. Gene
  3. Gpr50 - G-protein-coupled receptor 50 Gene

Gpr50 - G-protein-coupled receptor 50 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as H9

Gene ID: 14765 | Gene type: protein coding

About Gpr50

Summary

This gene encodes a multipass membrane protein that is thought to act as a G protein-coupled receptor. Activity of this protein may be important in neurotransmitter and glucocorticoid signalling. Mutation of this gene causes a decreased ability to maintain a constant body temperature, resulting in torpor, as well as an increased metabolic rate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Gpr50 Products(2)

mRNA Protein Name
NM_001308501.1 NP_001295430.1 melatonin-related receptor isoform 2
NM_010340.2 NP_034470.1 melatonin-related receptor isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21858214 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

melatonin-related receptor

Gpr50 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Gpr50 O88495 Kat5 Mus musculus Q8CHK4
Confocal
21858214
Intra
Gpr50 O88495 Kat5 Mus musculus Q8CHK4
Anti Tag CoIP
21858214
Intra
Gpr50 O88495 Kat5 Mus musculus Q8CHK4
Y2H
21858214
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05717 GPR50 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20942 Gpr50 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27459 Gpr50 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr50 NCBI NCBI:9248