Glrb - glycine receptor, beta subunit Gene

Mus musculus

Also known as spa; Glyrb; spastic

Gene ID: 14658 | Gene type: protein coding

About Glrb

Summary

This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. This gene is transcribed throughout the central nervous system of neonatal and adult mice. In humans, mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Glrb Products(17)

mRNA	Protein	Name
NM_001281969.3	NP_001268898.1	glycine receptor subunit beta isoform 7
NM_001345955.2	NP_001332884.1	glycine receptor subunit beta isoform 1 precursor
NM_001345956.2	NP_001332885.1	glycine receptor subunit beta isoform 2 precursor
NM_001345957.2	NP_001332886.1	glycine receptor subunit beta isoform 3 precursor
NM_001345958.2	NP_001332887.1	glycine receptor subunit beta isoform 6
NM_001345959.2	NP_001332888.1	glycine receptor subunit beta isoform 7
NM_001345996.2	NP_001332925.1	glycine receptor subunit beta isoform 5 precursor
NM_001410144.1	NP_001397073.1	glycine receptor subunit beta isoform 8
NM_001410145.1	NP_001397074.1	glycine receptor subunit beta isoform 6
NM_001410146.1	NP_001397075.1	glycine receptor subunit beta isoform 7
NM_001410147.1	NP_001397076.1	glycine receptor subunit beta isoform 7
NM_001410148.1	NP_001397077.1	glycine receptor subunit beta isoform 9
NM_001410149.1	NP_001397078.1	glycine receptor subunit beta isoform 9
NM_001410150.1	NP_001397079.1	glycine receptor subunit beta isoform 9
NM_001410151.1	NP_001397080.1	glycine receptor subunit beta isoform 10 precursor
NM_001410152.1	NP_001397081.1	glycine receptor subunit beta isoform 11 precursor
NM_010298.7	NP_034428.2	glycine receptor subunit beta isoform 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables extracellularly glycine-gated chloride channel activity	IMP IMP: Inferred from mutant phenotype	12809985	MGI
enables glycine binding	IMP IMP: Inferred from mutant phenotype	2983837	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17347650	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	16672662	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	16672662	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within acrosome reaction	IMP IMP: Inferred from mutant phenotype	11076688	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	4323808	MGI
acts upstream of or within gamma-aminobutyric acid receptor clustering	IGI IGI: Inferred from genetic interaction	19723286	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	8635460	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	16672662	MGI
acts upstream of or within righting reflex	IMP IMP: Inferred from mutant phenotype	6285205	MGI
acts upstream of or within synaptic transmission, glycinergic	IMP IMP: Inferred from mutant phenotype	1338094	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	1338094	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in GABA-ergic synapse	IDA IDA: Inferred from direct assay	19723286	MGI
located in dendrite	IDA IDA: Inferred from direct assay	19723286	MGI
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	16672662	MGI
is active in glycinergic synapse	IMP IMP: Inferred from mutant phenotype	16672662	MGI
located in membrane	IDA IDA: Inferred from direct assay	17145751	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glycine receptor subunit beta

glycine receptor 58 kDa subunit

inhibitory glycine receptor

Glrb Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Glrb	P48168	Gphn	Mus musculus	Q8BUV3	Pull Down	21829170
Cross	Glrb	P48168	Gphn	Rattus norvegicus	Q03555	Pull Down	21829170
Cross	Glrb	P48168	Gphn	Rattus norvegicus	Q03555	ITC	21829170

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05495	GLRB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22187	Glrb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28709	Glrb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Glrb	NCBI	NCBI:2743

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