Fech - ferrochelatase Gene

Mus musculus

Also known as Fcl; fch

Gene ID: 14151 | Gene type: protein coding

About Fech

Summary

Enables several functions, including ferrochelatase activity; heme binding activity; and iron-responsive element binding activity. Acts upstream of or within several processes, including porphyrin-containing compound metabolic process; regulation of cellular macromolecule biosynthetic process; and very-low-density lipoprotein particle assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including choroid plexus; heart; integumental system; liver and biliary system; and respiratory system. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Apr 2022]

Fech Products(2)

mRNA	Protein	Name
NM_001348055.2	NP_001334984.1	ferrochelatase, mitochondrial isoform 2
NM_007998.8	NP_032024.2	ferrochelatase, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ferrochelatase activity	IDA IDA: Inferred from direct assay	2246229	MGI
enables ferrochelatase activity	IMP IMP: Inferred from mutant phenotype	8325637	MGI
enables heme binding	IDA IDA: Inferred from direct assay	16503645	MGI
enables iron ion binding	IDA IDA: Inferred from direct assay	14981080	MGI
enables iron-responsive element binding	IDA IDA: Inferred from direct assay	7575558	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20427704	MGI
enables tetrapyrrole binding	IDA IDA: Inferred from direct assay	14981080	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	11160364	MGI
acts upstream of or within detection of UV	IMP IMP: Inferred from mutant phenotype	12149233	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	1939658	MGI
involved in heme A biosynthetic process	IMP IMP: Inferred from mutant phenotype	15677551	MGI
involved in heme B biosynthetic process	IMP IMP: Inferred from mutant phenotype	15677551	MGI
involved in heme O biosynthetic process	IMP IMP: Inferred from mutant phenotype	15677551	MGI
acts upstream of or within heme biosynthetic process	IDA IDA: Inferred from direct assay	15496139	MGI
acts upstream of or within heme biosynthetic process	IMP IMP: Inferred from mutant phenotype	8611576	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	17003376	MGI
acts upstream of or within porphyrin-containing compound biosynthetic process	IMP IMP: Inferred from mutant phenotype	12149233	MGI
acts upstream of or within protoporphyrinogen IX metabolic process	IGI IGI: Inferred from genetic interaction	15931390	MGI
acts upstream of or within regulation of eIF2 alpha phosphorylation by heme	IGI IGI: Inferred from genetic interaction	15931390	MGI
acts upstream of or within regulation of eIF2 alpha phosphorylation by heme	IMP IMP: Inferred from mutant phenotype	15931390	MGI
acts upstream of or within regulation of hemoglobin biosynthetic process	IGI IGI: Inferred from genetic interaction	15931390	MGI
acts upstream of or within response to light stimulus	IMP IMP: Inferred from mutant phenotype	1939658	MGI
acts upstream of or within very-low-density lipoprotein particle assembly	IMP IMP: Inferred from mutant phenotype	11160364	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	27599036	MGI
is active in mitochondrial matrix	IDA IDA: Inferred from direct assay	30366982	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ferrochelatase, mitochondrial

heme synthase	heme synthetase
protoheme ferro-lyase

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114758	Pyridoxal isonicotinoyl hydrazone	Inhibitor	99.96%	Unkown
HY-RS04857	FECH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20276	Fech Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26784	Fech Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fech	NCBI	NCBI:2235

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