Trpc5 - transient receptor potential cation channel, subfamily C, member 5 Gene

Rattus norvegicus

Also known as Trrp5

Gene ID: 140933 | Gene type: protein coding

About Trpc5

Summary

Enables ATPase binding activity; clathrin binding activity; and cytoskeletal protein binding activity. Involved in several processes, including generation of neurons; positive regulation of peptidyl-threonine phosphorylation; and regulation of membrane hyperpolarization. Located in several cellular components, including growth cone; membrane raft; and neuronal cell body. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Apr 2022]

Trpc5 Products(1)

mRNA	Protein	Name
NM_080898.3	NP_543174.1	short transient receptor potential channel 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	16025302	RGD
enables actin binding	IDA IDA: Inferred from direct assay	16025302	RGD
enables actinin binding	IDA IDA: Inferred from direct assay	16025302	RGD
enables clathrin binding	IDA IDA: Inferred from direct assay	16025302	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12857742	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	22764246	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	21618530	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	21984481	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21984481	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	22764246	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	20479868	RGD
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	22699894	RGD
involved in regulation of membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	21179559	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	22764246	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12858178	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	22764246	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

short transient receptor potential channel 5

transient receptor protein 5

Related Agents

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Purity	Rare Diseases
HY-17386	Rosiglitazone	99.94%	Yes
HY-14600	Rosiglitazone maleate	99.73%	Yes
HY-17386A	Rosiglitazone hydrochloride	99.81%	Yes
HY-30234A	Clemizole hydrochloride	99.99%	Yes
HY-17386B	Rosiglitazone potassium	/	Unkown
HY-14600R	Rosiglitazone maleate (Standard)	/	Unkown
HY-30234	Clemizole	/	Unkown
HY-B0700	Rosiglitazone sodium	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-162584	TRPC4/5-IN-2	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-133168	Englerin A	Activator	99.50%	Unkown
HY-12949	ML204	Inhibitor	98.45%	Unkown
HY-112302	HC-070	Antagonist	99.74%	Unkown
HY-122051	AC1903	Inhibitor	99.80%	Unkown
HY-128205	BTD	Inhibitor	99.78%	Unkown
HY-12949A	ML204 hydrochloride	Inhibitor	99.74%	Unkown
HY-132813	Evifacotrep	Antagonist	99.65%	Unkown
HY-133012	GFB-8438	Inhibitor	99.74%	Unkown
HY-145150	TRPC5-IN-1	Inhibitor	98.97%	Unkown
HY-17386S	Rosiglitazone-d3		/	Unkown
HY-128561	AM12	Activator	/	Unkown
HY-142030	TRPC5 modulator-1	Modulator	/	Unkown
HY-144205	TRPC5-IN-2	Inhibitor	/	Unkown
HY-144208	TRPC5-IN-3	Inhibitor	/	Unkown
HY-144429	TRPC5-IN-4	Inhibitor	/	Unkown
HY-146155	TRPC4/5-IN-1	Inhibitor	/	Unkown
HY-162090	TRPC antagonist 1	Antagonist	/	Unkown
HY-172106	TRPC5-IN-5	Inhibitor	/	Unkown
HY-172600	TRPC6 antagonist-1	Antagonist	/	Unkown
HY-RS15108	TRPC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W707161	4-Methyl-2-(1-piperidinyl)-quinoline-d10		/	Unkown
HY-17386S1	Rosiglitazone-d4		/	Unkown
HY-RS16614	Trpc5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23049	Trpc5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpc5	NCBI	NCBI:7224

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