2. Gene
  3. Nek8 - NIMA (never in mitosis gene a)-related expressed kinase 8 Gene

Nek8 - NIMA (never in mitosis gene a)-related expressed kinase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as jck; b2b1449Clo; 4632401F23Rik

Gene ID: 140859 | Gene type: protein coding

About Nek8

Summary

This gene encodes a NIMA-related kinase. Members of this serine/threonine protein kinase family are structurally-related to NIMA (never in Mitosis, gene A) which controls mitotic signaling in Aspergillus nidulans. [provided by RefSeq, Jul 2008]

Nek8 Products(1)

mRNA Protein Name
NM_080849.3 NP_543125.1 serine/threonine-protein kinase Nek8
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18235101 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
Cellular Component GO Annotation Evidence Reference Source
located in ciliary base IDA
IDA: Inferred from direct assay
20169535 MGI
located in ciliary inversin compartment IDA
IDA: Inferred from direct assay
20169535 MGI
located in cilium IDA
IDA: Inferred from direct assay
16267153 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek8

NIMA-related expressed kinase 8

juvenile cystic kidney

never in mitosis A-related kinase 8

nimA-related protein kinase 8

Nek8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Nek8 Q91ZR4 Invs Mus musculus O89019
Pull Down
22687244
Intra
Nek8 Q91ZR4 Invs Mus musculus O89019
Anti Tag CoIP
21565611
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09199 NEK8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21388 Nek8 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nek8 NCBI NCBI:284086