Ptk2 - PTK2 protein tyrosine kinase 2 Gene

Mus musculus

Also known as FAK; FRNK; Fadk; FADK 1; p125FAK

Gene ID: 14083 | Gene type: protein coding

About Ptk2

Chromosome 15: 73,076,951-73,295,129 reverse strand.GRCm39:CM001008.3

This gene has 16 transcripts (splice variants), 230 orthologues, 32 paralogues and is associated with 64 phenotypes. Ubiquitous expression in cortex adult (RPKM 12.3), CNS E11.5 (RPKM 11.8) and 28 other tissues.

Summary

Enables non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of cell population proliferation; positive regulation of ubiquitin-dependent protein catabolic process; and protein phosphorylation. Acts upstream of or within several processes, including blood vessel morphogenesis; generation of neurons; and peptidyl-tyrosine autophosphorylation. Located in several cellular components, including apical plasma membrane; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and yolk sac. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2 Products(3)

mRNA	Protein	Name
NM_001358045.1	NP_001344974.1	focal adhesion kinase 1 isoform 3
NM_001358046.1	NP_001344975.1	focal adhesion kinase 1 isoform 4
NM_007982.2	NP_032008.2	focal adhesion kinase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables non-membrane spanning protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	18297732	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7479864	MGI
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	16298995	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7529876	MGI
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	25059660	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	15967814	MGI
acts upstream of axonogenesis	IMP IMP: Inferred from mutant phenotype	15378065	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	12595342	MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	21829547	MGI
acts upstream of or within central nervous system neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	15378065	MGI
acts upstream of or within endothelial cell migration	IMP IMP: Inferred from mutant phenotype	15967814	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	14642275	MGI
acts upstream of or within microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	12941275	MGI
acts upstream of or within negative regulation of autophagy	IDA IDA: Inferred from direct assay	27994061	MGI
acts upstream of or within negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	27994061	MGI
acts upstream of or within negative regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	15378065	MGI
acts upstream of or within negative regulation of organ growth	IGI IGI: Inferred from genetic interaction	16374517	MGI
acts upstream of or within negative regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	15378065	MGI
acts upstream of or within neuron migration	IDA IDA: Inferred from direct assay	12941275	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	14642275	MGI
acts upstream of or within nuclear migration	IDA IDA: Inferred from direct assay	12941275	MGI
acts upstream of organ growth	IGI IGI: Inferred from genetic interaction	16374517	MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	27994061	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	27994061	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7529876	MGI
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	18297732	MGI
acts upstream of or within positive regulation of cardiac muscle hypertrophy	IDA IDA: Inferred from direct assay	27994061	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18206965	MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	18206965	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7529876	MGI
acts upstream of or within protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	2132399	MGI
involved in regulation of modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	19553453	MGI
involved in regulation of modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	19553453	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	15967814	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10742111	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	10699171	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19553453	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19553453	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	15728191	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18206965	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ptk2 Protein Structure

FERM_N_2

B41

FERM_C_FAK1

PTKc_FAK

Focal_AT

0
200
400
600
800
1000
1052 a.a.

Protein Preferred Names

Protein Names

focal adhesion kinase 1

focal adhesion kinase-related nonkinase	focal ashension kinase 1
pp125FAK	protein-tyrosine kinase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123919	TL13-112	Inhibitor	98.15%	Unkown
HY-111546	BI-3663	Inhibitor	99.84%	Unkown
HY-124625	BI-4464	Inhibitor	98.64%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-122582	TL13-12	Inhibitor	98.06%	Unkown
HY-130422	Tos-PEG4-t-butyl ester		/	Unkown
HY-130521	Pomalidomide-amido-PEG3-C2-NH2		99.55%	Unkown
HY-148065	FMF-06-098-1		98.77%	Unkown
HY-RS11400	Ptk2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-136194	TL13-22	Inhibitor	99.71%	Unkown
HY-136195	TL13-110	Inhibitor	/	Unkown
HY-RS11399	PTK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11401	Ptk2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11402	PTK2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptk2	NCBI	NCBI:5747

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