Abcc3 - ATP binding cassette subfamily C member 3 Gene

Rattus norvegicus

Also known as Mlp2; Mrp3

Gene ID: 140668 | Gene type: protein coding

About Abcc3

Summary

Enables ABC-type bile acid transporter activity. Involved in several processes, including anion transport; response to estradiol; and response to lipopolysaccharide. Acts upstream of or within canalicular bile acid transport. Located in basolateral plasma membrane. Biomarker of several diseases, including bilirubin metabolic disorder (multiple); fatty liver disease (multiple); hepatocellular carcinoma; hyperprolactinemia; and kidney disease (multiple). Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]

Abcc3 Products(1)

mRNA	Protein	Name
NM_080581.2	NP_542148.2	ATP-binding cassette sub-family C member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ABC-type bile acid transporter activity	IDA IDA: Inferred from direct assay	10644759	RGD
enables ATPase-coupled transmembrane transporter activity	IDA IDA: Inferred from direct assay	10362653	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bile acid and bile salt transport	IMP IMP: Inferred from mutant phenotype	10644759	RGD
acts upstream of or within canalicular bile acid transport	IDA IDA: Inferred from direct assay	10362653	RGD
involved in monoatomic anion transmembrane transport	IDA IDA: Inferred from direct assay	11837698	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16554369	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18505788	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18648771	RGD
involved in response to tetrachloromethane	IEP IEP: Inferred from expression pattern	17544377	RGD
involved in transmembrane transport	IMP IMP: Inferred from mutant phenotype	12909565	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11897632	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18698235	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family C member 3

canalicular multispecific organic anion transporter 2

ATP-binding cassette, sub-family C (CFTR/MRP), member 3	ATP-binding cassette, subfamily C (CFTR/MRP), member 3
MLP-2	MRP-like protein 2
multidrug resistance protein 3	multidrug resistance-associated protein 3
organic anion transporter

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00062	ABCC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19977	Abcc3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26480	Abcc3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcc3	NCBI	NCBI:8714

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