Etv6 - ets variant 6 Gene

Mus musculus

Also known as Tel

Gene ID: 14011 | Gene type: protein coding

About Etv6

Summary

This gene encodes a transcriptional repressor belonging to the ETS family of proteins. Knockout of this gene in mice results in embryonic lethality due to defective angiogenesis. In humans, this gene is often involved in chromosome rearrangements associated with specific cancers. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Etv6 Products(2)

mRNA	Protein	Name
NM_001303102.1	NP_001290031.1	transcription factor ETV6 isoform 2
NM_007961.4	NP_031987.3	transcription factor ETV6 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12527908	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17606295	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12527908	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17606295	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12527908	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell differentiation	IDA IDA: Inferred from direct assay	12527908	MGI
acts upstream of or within mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9250681	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	9250681	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17606295	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12527908	MGI
acts upstream of or within vitellogenesis	IMP IMP: Inferred from mutant phenotype	9250681	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor ETV6

ETS-related protein Tel1	ets variant gene 6 (TEL oncogene)
translocation-ets-leukemia

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146807	Type II TRK inhibitor 1	Inhibitor	/	Unkown
HY-155046	FGFR4-IN-14	Inhibitor	/	Unkown
HY-163366	TRK-IN-28	Inhibitor	/	Unkown
HY-RS04569	ETV6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19598	Etv6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26094	Etv6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Etv6	NCBI	NCBI:2120

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